Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium
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Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium. / Kjærulff, Louise; Nielsen, Anita; Mansson, Maria; Gram, Lone; Larsen, Thomas Ostenfeld; Ingmer, Hanne; Gotfredsen, Charlotte Held.
I: Marine Drugs, Bind 11, Nr. 12, 2013, s. 5051-5062.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium
AU - Kjærulff, Louise
AU - Nielsen, Anita
AU - Mansson, Maria
AU - Gram, Lone
AU - Larsen, Thomas Ostenfeld
AU - Ingmer, Hanne
AU - Gotfredsen, Charlotte Held
PY - 2013
Y1 - 2013
N2 - During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans. The chemical fingerprint of the bacterium showed primarily non-ribosomal peptide synthetase (NRPS)-like compounds, including the known pyrrothine antibiotic holomycin and a wide range of peptides, from diketopiperazines to cyclodepsipeptides of 500-900 Da. Purification of components from the pellet fraction led to the isolation and structure elucidation of four new cyclodepsipeptides, ngercheumicin F, G, H, and I. The ngercheumicins interfered with expression of virulence genes known to be controlled by the agr quorum sensing system of Staphylococcus aureus, although to a lesser extent than the previously described solonamides from the same strain of Photobacterium.
AB - During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans. The chemical fingerprint of the bacterium showed primarily non-ribosomal peptide synthetase (NRPS)-like compounds, including the known pyrrothine antibiotic holomycin and a wide range of peptides, from diketopiperazines to cyclodepsipeptides of 500-900 Da. Purification of components from the pellet fraction led to the isolation and structure elucidation of four new cyclodepsipeptides, ngercheumicin F, G, H, and I. The ngercheumicins interfered with expression of virulence genes known to be controlled by the agr quorum sensing system of Staphylococcus aureus, although to a lesser extent than the previously described solonamides from the same strain of Photobacterium.
KW - Faculty of Health and Medical Sciences
KW - Photobacterium
KW - depsipeptide
KW - structure elucidation
KW - quorum sensing
KW - antivirulence
KW - agr
U2 - 10.3390/md11125051
DO - 10.3390/md11125051
M3 - Journal article
C2 - 24351904
VL - 11
SP - 5051
EP - 5062
JO - Marine Drugs
JF - Marine Drugs
SN - 1660-3397
IS - 12
ER -
ID: 99345285