Natural antioxidants in chemoprevention
Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
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Natural antioxidants in chemoprevention. / Dragsted, Lars Ove.
Diversification in Toxicology - Man and Environment. red. / J P Seiler. Heidelberg : Springer, 1998. s. 209-226 (Archives of Toxicology, Bind 20).Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
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TY - GEN
T1 - Natural antioxidants in chemoprevention
AU - Dragsted, Lars Ove
N1 - (Ekstern)
PY - 1998
Y1 - 1998
N2 - It is well documented that diets rich in fruits and vegetables can reduce the risk of most common cancers, and that some food items from this class may be protective against heart disease. Several explanations have been offered, one of which relates to the natural presence of potent antioxidants in plant products. Destructive oxidation of lipids, proteins, DNA, and other important biomolecules, often involving radical chain reactions, affect vital cellular structures and their normal functions. Such processes are involved in the development of cancer as well as heart disease, and it seems logical to assume that antioxidants might be preventive. Large human trials with natural antioxidants have not provided a uniform support, however, for the hypothesis that antioxidation per se may prevent cancer or coronary heart disease (CHD)1. One reason is that other effects, unrelated to antioxidation, may compromise their preventive effects. Another reason may be that many potent antioxidants can also act as pro-oxidants under certain conditions. The interpretation of animal trials is likewise often compromised by the fact that most antioxidants have other physiological effects which might very well explain their protective action or lead to toxic side-effects. In addition, absorption, metabolism and distribution may profoundly influence their antioxidant actions, and not all cellular compartments are equally well protected. Furthermore, interactions between antioxidant systems are only partially understood.
AB - It is well documented that diets rich in fruits and vegetables can reduce the risk of most common cancers, and that some food items from this class may be protective against heart disease. Several explanations have been offered, one of which relates to the natural presence of potent antioxidants in plant products. Destructive oxidation of lipids, proteins, DNA, and other important biomolecules, often involving radical chain reactions, affect vital cellular structures and their normal functions. Such processes are involved in the development of cancer as well as heart disease, and it seems logical to assume that antioxidants might be preventive. Large human trials with natural antioxidants have not provided a uniform support, however, for the hypothesis that antioxidation per se may prevent cancer or coronary heart disease (CHD)1. One reason is that other effects, unrelated to antioxidation, may compromise their preventive effects. Another reason may be that many potent antioxidants can also act as pro-oxidants under certain conditions. The interpretation of animal trials is likewise often compromised by the fact that most antioxidants have other physiological effects which might very well explain their protective action or lead to toxic side-effects. In addition, absorption, metabolism and distribution may profoundly influence their antioxidant actions, and not all cellular compartments are equally well protected. Furthermore, interactions between antioxidant systems are only partially understood.
KW - Faculty of Science
KW - Coronary heart disease
KW - Natural antioxidant
KW - Macrophage scavenger receptor
KW - Hamster buccal pouch
KW - Morin hydrate
UR - http://www.scopus.com/inward/record.url?scp=0031607310&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-46856-8_19
DO - 10.1007/978-3-642-46856-8_19
M3 - Article in proceedings
C2 - 9442295
AN - SCOPUS:0031607310
T3 - Archives of Toxicology
SP - 209
EP - 226
BT - Diversification in Toxicology - Man and Environment
A2 - Seiler, J P
PB - Springer
CY - Heidelberg
ER -
ID: 254772238