Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands
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Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
Originalsprog | Engelsk |
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Tidsskrift | Bioorganic & Medicinal Chemistry Letters |
Vol/bind | 20 |
Udgave nummer | 18 |
Sider (fra-til) | 5431-5433 |
ISSN | 0960-894X |
DOI | |
Status | Udgivet - 15 sep. 2010 |
Bibliografisk note
Keywords: carbene, C-H insertion, serotonin, 5-HT2C, 5-HT6, 1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole
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Forskningsområder
ID: 34207860