Obesity, hypovitaminosis D, and COVID-19: the Bermuda Triangle in public health
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Purpose of review: The COVID-19 pandemic has challenged public health to a significant extent by markedly increasing morbidity and mortality. Evidence suggests that obesity and hypovitaminosis D constitute important risk factors for SARS-CoV-2 infection, severity of disease, and poor outcomes. Due to their high prevalence globally, obesity and hypovitaminosis D are considered pandemics. This review presents current epidemiologic and genetic data linking obesity, hypovitaminosis D, and COVID-19, highlighting the importance of the convergence of three pandemics and their impact on public health. We also briefly summarize potential mechanisms that could explain these links.
Recent findings: Epidemiologic data have shown that obesity is an independent risk factor for COVID-19, severe disease and death, and genetic evidence has suggested a causal association between obesity-related traits and COVID-19 susceptibility and severity. Additionally, obesity is independently associated with hypovitaminosis D, which is highly prevalent in subjects with obesity. Hypovitaminosis D is independently associated with a higher risk for COVID-19, severity, hospitalization, infectious complications, acute respiratory distress syndrome, and poor outcomes. However, genome-wide association studies have not revealed any causal association between vitamin D levels and the risk for COVID-19, while there is no robust evidence for a beneficial role of vitamin D supplementation in the prevention and treatment of COVID-19.
Summary: In the context of the ongoing COVID-19 pandemic, the epidemiologic impact of obesity and hypovitaminosis D is emphasized. Efforts to increase public awareness and reinforce preventive and therapeutic measures against obesity and hypovitaminosis D are strongly required.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Current Obesity Reports |
Vol/bind | 11 |
Udgave nummer | 3 |
Sider (fra-til) | 116-125 |
Antal sider | 10 |
ISSN | 2162-4968 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
CURIS 2022 NEXS 102
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- Det Natur- og Biovidenskabelige Fakultet
Forskningsområder
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989103/pdf/13679_2022_Article_471.pdf
Forlagets udgivne version
ID: 302905907