Partial agonists and subunit selectivity at NMDA receptors
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
Originalsprog | Engelsk |
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Tidsskrift | Chemistry: A European Journal |
Vol/bind | 16 |
Udgave nummer | 47 |
Sider (fra-til) | 13910-13918 |
ISSN | 0947-6539 |
DOI | |
Status | Udgivet - 17 dec. 2010 |
Bibliografisk note
Keywords: agonists, glutamate, ligand design, receptors, subunit selectivity
- Det tidligere Farmaceutiske Fakultet
Forskningsområder
ID: 33701222