Plasma vitamin B12 concentration is positively associated with cognitive development in healthy Danish 3-year-old children: the SKOT cohort studies
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Plasma vitamin B12 concentration is positively associated with cognitive development in healthy Danish 3-year-old children: the SKOT cohort studies. / Larnkjær, Anni; Christensen, Sophie Hilario; Lind, Mads Vendelbo; Michaelsen, Kim F.; Mølgaard, Christian.
I: British Journal of Nutrition, Bind 128, Nr. 10, 2022, s. 1946-1954.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Plasma vitamin B12 concentration is positively associated with cognitive development in healthy Danish 3-year-old children: the SKOT cohort studies
AU - Larnkjær, Anni
AU - Christensen, Sophie Hilario
AU - Lind, Mads Vendelbo
AU - Michaelsen, Kim F.
AU - Mølgaard, Christian
N1 - CURIS 2022 NEXS 030
PY - 2022
Y1 - 2022
N2 - Adequate vitamin B12 (B12)and folate concentrations are essential for neural development in early childhood but studies in well-nourished children are lacking. We investigated the relation between plasma B12 and folate at 9 and 36 months and psychomotor development at 36 months in well-nourished Danish children. Subjects from the SKOT cohorts with B12 measurement and completed Ages and Stages Questionnaire, 3rd edition (ASQ-3) at 36 months were included (n=280). Dietary intake, B12 and folate concentrations were collected at 9 and 36 months, and ASQ-3 was assessed at 36 months. Associations between vitamin B12 and folate at 9 and 36 months and ASQ-3 were analyzed using regression models. Associations between diet and vitamin B12 were also investigated. No children had insufficient B12 (<148pmol/L) at 36 months. B12 at 36 month was positively associated with total ASQ-3 corresponding to an increase of 100 pmol/l B12 per 1.5 increase in total ASQ-3 score (P = 0.019) which remained significant after adjustment for potential confounders including 9 months values. B12 at 9 months or folate at any time point was not associated with total ASQ-3. Intake of milk products was associated with B12 at 36 months (P = 0.003) and showed a trend at 9 months (P = 0.069). Intake of meat products was not associated with B12. In conclusion, B12 was positively related to psychomotor development at 3 years in well-nourished children, indicating that the impact of having marginally low B12 status on psychomotor development in well-nourished children should be examined further.
AB - Adequate vitamin B12 (B12)and folate concentrations are essential for neural development in early childhood but studies in well-nourished children are lacking. We investigated the relation between plasma B12 and folate at 9 and 36 months and psychomotor development at 36 months in well-nourished Danish children. Subjects from the SKOT cohorts with B12 measurement and completed Ages and Stages Questionnaire, 3rd edition (ASQ-3) at 36 months were included (n=280). Dietary intake, B12 and folate concentrations were collected at 9 and 36 months, and ASQ-3 was assessed at 36 months. Associations between vitamin B12 and folate at 9 and 36 months and ASQ-3 were analyzed using regression models. Associations between diet and vitamin B12 were also investigated. No children had insufficient B12 (<148pmol/L) at 36 months. B12 at 36 month was positively associated with total ASQ-3 corresponding to an increase of 100 pmol/l B12 per 1.5 increase in total ASQ-3 score (P = 0.019) which remained significant after adjustment for potential confounders including 9 months values. B12 at 9 months or folate at any time point was not associated with total ASQ-3. Intake of milk products was associated with B12 at 36 months (P = 0.003) and showed a trend at 9 months (P = 0.069). Intake of meat products was not associated with B12. In conclusion, B12 was positively related to psychomotor development at 3 years in well-nourished children, indicating that the impact of having marginally low B12 status on psychomotor development in well-nourished children should be examined further.
KW - Faculty of Science
KW - Early childhood
KW - Vitamin B12 status
KW - Development
KW - Cognition
KW - Folate
U2 - 10.1017/S0007114521004888
DO - 10.1017/S0007114521004888
M3 - Journal article
C2 - 34913420
VL - 128
SP - 1946
EP - 1954
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
ER -
ID: 287693136