Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [(11)C]Cimbi-5 in different ways. Here, we present the in vivo validation of nine novel 5-HT(2A) receptor agonist PET tracers in the pig brain.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Nuclear Medicine and Molecular Imaging |
Vol/bind | 38 |
Udgave nummer | 4 |
Sider (fra-til) | 681-693 |
ISSN | 1619-7070 |
DOI | |
Status | Udgivet - 1 apr. 2011 |
Bibliografisk note
Keywords: PET tracer development, 5-HT(2A), agonist, porcine, serotonin receptors, [11C]Cimbi-36
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