A Wnt oscillator model for somitogenesis
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A Wnt oscillator model for somitogenesis. / Jensen, Peter B; Pedersen, Lykke; Krishna, Sandeep; Jensen, Mogens H.
I: Biophysical Journal, Bind 98, Nr. 6, 17.03.2010, s. 943-950.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A Wnt oscillator model for somitogenesis
AU - Jensen, Peter B
AU - Pedersen, Lykke
AU - Krishna, Sandeep
AU - Jensen, Mogens H
N1 - Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
PY - 2010/3/17
Y1 - 2010/3/17
N2 - We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often spiky, where low concentration values of beta-catenin are interrupted by sharp peaks. Necessary for the oscillations is the saturated degradation of Axin2. Somite formation in chick and mouse embryos is controlled by a spatial Wnt gradient which we introduce in the model through a time-dependent decrease in Wnt3a ligand level. We find that the oscillations disappear as the ligand concentration decreases, in agreement with observations on embryos.
AB - We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often spiky, where low concentration values of beta-catenin are interrupted by sharp peaks. Necessary for the oscillations is the saturated degradation of Axin2. Somite formation in chick and mouse embryos is controlled by a spatial Wnt gradient which we introduce in the model through a time-dependent decrease in Wnt3a ligand level. We find that the oscillations disappear as the ligand concentration decreases, in agreement with observations on embryos.
KW - Animals
KW - Biological Clocks
KW - Computer Simulation
KW - Embryonic Development
KW - Humans
KW - Models, Biological
KW - Somites
KW - Wnt Proteins
U2 - 10.1016/j.bpj.2009.11.039
DO - 10.1016/j.bpj.2009.11.039
M3 - Journal article
C2 - 20303851
VL - 98
SP - 943
EP - 950
JO - Biophysical Journal
JF - Biophysical Journal
SN - 0006-3495
IS - 6
ER -
ID: 32671790