GDF15 in appetite and exercise: Essential player or coincidental bystander?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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GDF15 in appetite and exercise: Essential player or coincidental bystander? / Klein, Anders Bue; Kleinert, Maximilian; Richter, Erik A.; Clemmensen, Christoffer.
I: Endocrinology, Bind 163, Nr. 1, 2022, s. 1-10.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - GDF15 in appetite and exercise: Essential player or coincidental bystander?
AU - Klein, Anders Bue
AU - Kleinert, Maximilian
AU - Richter, Erik A.
AU - Clemmensen, Christoffer
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2022
Y1 - 2022
N2 - Growth differentiation factor 15 (GDF15) has recently moved to the forefront of metabolism research. When administered pharmacologically, GDF15 reduces food intake and lowers body weight via the hindbrain-situated receptor GFRAL (glial cell-derived neurotrophic factor family receptor alpha like). Endogenous GDF15 is a ubiquitous cellular stress signal that can be produced and secreted by a variety of cell types. Circulating levels are elevated in a series of disease states, but also in response to exogenous agents such as metformin, colchicine, AICAR and cisplatin. Recently, exercise has emerged as a relevant intervention to interrogate GDF15 physiology. Prolonged endurance exercise increases circulating GDF15 to levels otherwise associated with certain pathological states and in response to metformin treatment. Yet, the jury is still out as to whether GDF15 is a functional 'exerkine' mediating organ-to-brain cross-talk or whether it is a coincidental bystander. In this review, we discuss the putative physiological implication of exercise-induced GDF15, focusing on the potential impact on appetite and metabolism.
AB - Growth differentiation factor 15 (GDF15) has recently moved to the forefront of metabolism research. When administered pharmacologically, GDF15 reduces food intake and lowers body weight via the hindbrain-situated receptor GFRAL (glial cell-derived neurotrophic factor family receptor alpha like). Endogenous GDF15 is a ubiquitous cellular stress signal that can be produced and secreted by a variety of cell types. Circulating levels are elevated in a series of disease states, but also in response to exogenous agents such as metformin, colchicine, AICAR and cisplatin. Recently, exercise has emerged as a relevant intervention to interrogate GDF15 physiology. Prolonged endurance exercise increases circulating GDF15 to levels otherwise associated with certain pathological states and in response to metformin treatment. Yet, the jury is still out as to whether GDF15 is a functional 'exerkine' mediating organ-to-brain cross-talk or whether it is a coincidental bystander. In this review, we discuss the putative physiological implication of exercise-induced GDF15, focusing on the potential impact on appetite and metabolism.
KW - Faculty of Science
KW - Exercise
KW - GDF15
KW - Growth differentiation factor 15
KW - Appetite
KW - Energy balance
KW - Exerkine
U2 - 10.1210/endocr/bqab242
DO - 10.1210/endocr/bqab242
M3 - Review
C2 - 34849709
VL - 163
SP - 1
EP - 10
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0013-7227
IS - 1
ER -
ID: 286422671