Genetic regulation of fluxes: iron homeostasis of Escherichia coli
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Genetic regulation of fluxes : iron homeostasis of Escherichia coli. / Semsey, Szabolcs; Andersson, Anna M C; Krishna, Sandeep; Jensen, Mogens Høgh; Massé, Eric; Sneppen, Kim.
I: Nucleic Acids Research, Bind 34, Nr. 17, 2006, s. 4960-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic regulation of fluxes
T2 - iron homeostasis of Escherichia coli
AU - Semsey, Szabolcs
AU - Andersson, Anna M C
AU - Krishna, Sandeep
AU - Jensen, Mogens Høgh
AU - Massé, Eric
AU - Sneppen, Kim
PY - 2006
Y1 - 2006
N2 - Iron is an essential trace-element for most organisms. However, because high concentration of free intracellular iron is cytotoxic, cells have developed complex regulatory networks that keep free intracellular iron concentration at optimal range, allowing the incorporation of the metal into iron-using enzymes and minimizing damage to the cell. We built a mathematical model of the network that controls iron uptake and usage in the bacterium Escherichia coli to explore the dynamics of iron flow. We simulate the effect of sudden decrease or increase in the extracellular iron level on intracellular iron distribution. Based on the results of simulations we discuss the possible roles of the small RNA RyhB and the Fe-S cluster assembly systems in the optimal redistribution of iron flows. We suggest that Fe-S cluster assembly is crucial to prevent the accumulation of toxic levels of free intracellular iron when the environment suddenly becomes iron rich.
AB - Iron is an essential trace-element for most organisms. However, because high concentration of free intracellular iron is cytotoxic, cells have developed complex regulatory networks that keep free intracellular iron concentration at optimal range, allowing the incorporation of the metal into iron-using enzymes and minimizing damage to the cell. We built a mathematical model of the network that controls iron uptake and usage in the bacterium Escherichia coli to explore the dynamics of iron flow. We simulate the effect of sudden decrease or increase in the extracellular iron level on intracellular iron distribution. Based on the results of simulations we discuss the possible roles of the small RNA RyhB and the Fe-S cluster assembly systems in the optimal redistribution of iron flows. We suggest that Fe-S cluster assembly is crucial to prevent the accumulation of toxic levels of free intracellular iron when the environment suddenly becomes iron rich.
KW - Biological Transport
KW - Escherichia coli
KW - Escherichia coli Proteins
KW - Gene Expression Regulation, Bacterial
KW - Homeostasis
KW - Iron
KW - Iron-Sulfur Proteins
KW - Kinetics
KW - Models, Biological
KW - Systems Biology
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1093/nar/gkl627
DO - 10.1093/nar/gkl627
M3 - Journal article
C2 - 16982641
VL - 34
SP - 4960
EP - 4967
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - 17
ER -
ID: 163917719