1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Medicinal Chemistry |
Vol/bind | 51 |
Udgave nummer | 20 |
Sider (fra-til) | 6614-8 |
ISSN | 0022-2623 |
DOI | |
Status | Udgivet - 2008 |
- Det tidligere Farmaceutiske Fakultet
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ID: 6747715