Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications. / Kermani, Abbas Jafari; Harkness, Linda; Zaher, Walid; Kassem, Moustapha Saad El-Deen.
Adult Stem Cells : Stem Cell Biology and Regenerative Medicine. red. / Kursad Turksen. New York : Humana Press, 2014. s. 359-373.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications
AU - Kermani, Abbas Jafari
AU - Harkness, Linda
AU - Zaher, Walid
AU - Kassem, Moustapha Saad El-Deen
PY - 2014
Y1 - 2014
N2 - Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.
AB - Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.
KW - Faculty of Health and Medical Sciences
KW - Mesenchymal stem cells
KW - MSC-like cells
KW - Pluripotent stem cells
KW - Homing
KW - In vivo targeting
U2 - 10.1007/978-1-4614-9569-7_15
DO - 10.1007/978-1-4614-9569-7_15
M3 - Book chapter
SN - 978-1-4614-9568-0
SP - 359
EP - 373
BT - Adult Stem Cells
A2 - Turksen, Kursad
PB - Humana Press
CY - New York
ER -
ID: 138176649