Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats
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Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats. / Pedersen, Mikael Egebjerg; Baldwin, Roger A; Niquet, Jerome; Stafford, Gary Ivan; van Staden, Johannes; Wasterlain, Claude G; Jäger, Anna Katharina.
I: Phytotherapy Research, Bind 24, Nr. 6, 2010, s. 924-927.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats
AU - Pedersen, Mikael Egebjerg
AU - Baldwin, Roger A
AU - Niquet, Jerome
AU - Stafford, Gary Ivan
AU - van Staden, Johannes
AU - Wasterlain, Claude G
AU - Jäger, Anna Katharina
N1 - Keywords: traditional medicine; epilepsy; NMDA receptor antagonists
PY - 2010
Y1 - 2010
N2 - Searsia species are used in South Africa to treat epilepsy. Previous studies have demonstrated an in vitro N-methyl-D-aspartic acid (NMDA) receptor antagonistic effect of the ethanolic leaf extract. The aim of this study was to evaluate the potential anticonvulsant properties of the ethanolic extract of S. dentata in various animal models of epilepsy. The extract was submitted to a screening in anticonvulsant assays including NMDA-, kainic acid (KA)-, pentylenetetrazol (PTZ)- and bicuculline (BIC)-induced seizures in rats. The extract protected 47% of the PN 18 Wistar pups (postnatal day 18, date of birth PN 0) (p < 0.05, n > 10) against NMDA-induced seizures and significantly delayed the onset of PTZ-induced seizures (p < 0.05, n > 8) at a dose of 250 mg/kg. A dose optimum was detected at 500 mg/kg for protection against KA-(63% protection, p < 0.05, n > 8) and BIC-induced seizures (50% protection, p < 0.05, n > 8) in young adult and PN 18 rats, respectively. The ethanolic extract of S. dentata showed anticonvulsive properties in several models of epilepsy. These results are compatible with previous findings of NMDA receptor antagonism. Due to the complex composition of the extract, the effect might be caused by more than one compound. Copyright (c) 2009 John Wiley & Sons, Ltd.
AB - Searsia species are used in South Africa to treat epilepsy. Previous studies have demonstrated an in vitro N-methyl-D-aspartic acid (NMDA) receptor antagonistic effect of the ethanolic leaf extract. The aim of this study was to evaluate the potential anticonvulsant properties of the ethanolic extract of S. dentata in various animal models of epilepsy. The extract was submitted to a screening in anticonvulsant assays including NMDA-, kainic acid (KA)-, pentylenetetrazol (PTZ)- and bicuculline (BIC)-induced seizures in rats. The extract protected 47% of the PN 18 Wistar pups (postnatal day 18, date of birth PN 0) (p < 0.05, n > 10) against NMDA-induced seizures and significantly delayed the onset of PTZ-induced seizures (p < 0.05, n > 8) at a dose of 250 mg/kg. A dose optimum was detected at 500 mg/kg for protection against KA-(63% protection, p < 0.05, n > 8) and BIC-induced seizures (50% protection, p < 0.05, n > 8) in young adult and PN 18 rats, respectively. The ethanolic extract of S. dentata showed anticonvulsive properties in several models of epilepsy. These results are compatible with previous findings of NMDA receptor antagonism. Due to the complex composition of the extract, the effect might be caused by more than one compound. Copyright (c) 2009 John Wiley & Sons, Ltd.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1002/ptr.3016
DO - 10.1002/ptr.3016
M3 - Journal article
C2 - 19953526
VL - 24
SP - 924
EP - 927
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 6
ER -
ID: 20074644