Antioxidant activity and phenylpropanoids of Phlomis lychnitis L. A traditional herbal tea
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Antioxidant activity and phenylpropanoids of Phlomis lychnitis L. A traditional herbal tea. / López, Víctor; Jäger, Anna Katharina; Akerreta, Silvia; Cavero, Rita Yolanda; Calvo, Maria Isabel.
I: Plant Foods for Human Nutrition, Bind 65, Nr. 2, 2010, s. 179-185.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Antioxidant activity and phenylpropanoids of Phlomis lychnitis L.
T2 - A traditional herbal tea
AU - López, Víctor
AU - Jäger, Anna Katharina
AU - Akerreta, Silvia
AU - Cavero, Rita Yolanda
AU - Calvo, Maria Isabel
N1 - Keywords: Phlomis lychnitis; Lamiaceae; Antioxidant; PC12 cells; Verbascoside; Phenylpropanoids
PY - 2010
Y1 - 2010
N2 - Phlomis lychnitis L. (Lamiaceae) is consumed as a traditional herbal tea in Spain. The antioxidant-protective effects as well as its phytoconstituents have never been established. The ability of the methanolic extract to protect cells from oxidative stress was evaluated in rat pheochromocytoma cells (PC12) using hydrogen peroxide as toxic agent. The viability of PC12 cells pre-treated with the methanolic extract of Phlomis lychnitis, determined by the MTT and LDH assays, was significantly improved at the highest dose (p < 0.01). The antioxidant activity was confirmed evaluating the capacity of the plant to scavenge ABTS, DPPH, O(2) . (-) radicals and to inhibit XO. Bioassay guided fractionation led to antioxidant compounds. Qualitative HPLC/DAD/ESI/MS analysis reported phenylpropanoids, verbascoside being the major antioxidant constituent.
AB - Phlomis lychnitis L. (Lamiaceae) is consumed as a traditional herbal tea in Spain. The antioxidant-protective effects as well as its phytoconstituents have never been established. The ability of the methanolic extract to protect cells from oxidative stress was evaluated in rat pheochromocytoma cells (PC12) using hydrogen peroxide as toxic agent. The viability of PC12 cells pre-treated with the methanolic extract of Phlomis lychnitis, determined by the MTT and LDH assays, was significantly improved at the highest dose (p < 0.01). The antioxidant activity was confirmed evaluating the capacity of the plant to scavenge ABTS, DPPH, O(2) . (-) radicals and to inhibit XO. Bioassay guided fractionation led to antioxidant compounds. Qualitative HPLC/DAD/ESI/MS analysis reported phenylpropanoids, verbascoside being the major antioxidant constituent.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1007/s11130-010-0169-1
DO - 10.1007/s11130-010-0169-1
M3 - Journal article
C2 - 20422294
VL - 65
SP - 179
EP - 185
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
SN - 0921-9668
IS - 2
ER -
ID: 19844948