Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art: review article
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Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art : review article. / Harrison, Adrian Paul; Pierzynowski, S.G.
I: Journal of Physiology and Pharmacology, Bind 59, Nr. Suppl. 1, 2008, s. 91-106.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art
T2 - review article
AU - Harrison, Adrian Paul
AU - Pierzynowski, S.G.
PY - 2008
Y1 - 2008
N2 - The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state- of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alphaketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaied bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.
AB - The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state- of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alphaketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaied bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.
KW - Former LIFE faculty
KW - 2-oxoglutarate
KW - alpha keto glutarate (AKG)
KW - osteoporoses
KW - melatonin
KW - cholesterol
KW - cancer
KW - collagen
KW - muscle
KW - artery elasticity
KW - mineral absorption
M3 - Journal article
VL - 59
SP - 91
EP - 106
JO - Journal of Physiology and Pharmacology
JF - Journal of Physiology and Pharmacology
SN - 0867-5910
IS - Suppl. 1
ER -
ID: 8113466