First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization
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First total synthesis of (+/-)-3-hydroxy-11-norcytisine : Structure confirmation and biological characterization. / Yohannes, Daniel; Hansen, Camilla Petrycer; Akireddy, Srinivasa Rao; Hauser, Terry A; Kiser, Melanie N; Gurnon, Nicholas J; Day, Cynthia S; Bhatti, Balwinder; Caldwell, William S.
I: Organic Letters, Bind 10, Nr. 23, 2008, s. 5353-5356.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - First total synthesis of (+/-)-3-hydroxy-11-norcytisine
T2 - Structure confirmation and biological characterization
AU - Yohannes, Daniel
AU - Hansen, Camilla Petrycer
AU - Akireddy, Srinivasa Rao
AU - Hauser, Terry A
AU - Kiser, Melanie N
AU - Gurnon, Nicholas J
AU - Day, Cynthia S
AU - Bhatti, Balwinder
AU - Caldwell, William S
PY - 2008
Y1 - 2008
N2 - The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
AB - The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1021/ol802145b
DO - 10.1021/ol802145b
M3 - Journal article
C2 - 19007172
VL - 10
SP - 5353
EP - 5356
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 23
ER -
ID: 10162587