IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
Originalsprog | Engelsk |
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Tidsskrift | Allergy: European Journal of Allergy and Clinical Immunology |
Vol/bind | 68 |
Udgave nummer | 5 |
Sider (fra-til) | 614-620 |
Antal sider | 7 |
ISSN | 0105-4538 |
DOI | |
Status | Udgivet - 2013 |
- Det Sundhedsvidenskabelige Fakultet - Basophils, IgE-mediated activation, monocytes, tissue remodelling, TNF-alpha
Forskningsområder
ID: 45791918