Neuroprotective and neurological properties of Melissa officinalis
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Neuroprotective and neurological properties of Melissa officinalis. / López, Víctor; Martín, Sara; Gómez-Serranillos, Maria Pilar; Carretero, Maria Emilia; Jäger, Anna Katharina; Calvo, Maria Isabel.
I: Neurochemical Research, Bind 34, Nr. 11, 2009, s. 1955-1961.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neuroprotective and neurological properties of Melissa officinalis
AU - López, Víctor
AU - Martín, Sara
AU - Gómez-Serranillos, Maria Pilar
AU - Carretero, Maria Emilia
AU - Jäger, Anna Katharina
AU - Calvo, Maria Isabel
N1 - Keywords: Melissa officinalis; Traditional medicine; Neuroprotective; PC12; Antioxidant; MAO
PY - 2009
Y1 - 2009
N2 - Melissa officinalis has traditionally been used due to its effects on nervous system. Both methanolic and aqueous extracts were tested for protective effects on the PC12 cell line, free radical scavenging properties and neurological activities (inhibition of MAO-A and acetylcholinesterase enzymes and affinity to the GABA(A)-benzodiazepine receptor). The results suggest that the plant has a significant (P < 0.05) protective effect on hydrogen peroxide induced toxicity in PC12 cells. The radical scavenging properties were also investigated in cells and in cell free systems, where this plant was shown to be a good free radical scavenger. The MAO-A bioassay was also performed to detect possible antidepressant activities demonstrating that both extracts inhibited this enzyme, which has a key role in neurotransmitters metabolism. However, no activity was detected in the acetylcholinesterase and GABA assays. In general, the methanolic extract was more effective than the aqueous.
AB - Melissa officinalis has traditionally been used due to its effects on nervous system. Both methanolic and aqueous extracts were tested for protective effects on the PC12 cell line, free radical scavenging properties and neurological activities (inhibition of MAO-A and acetylcholinesterase enzymes and affinity to the GABA(A)-benzodiazepine receptor). The results suggest that the plant has a significant (P < 0.05) protective effect on hydrogen peroxide induced toxicity in PC12 cells. The radical scavenging properties were also investigated in cells and in cell free systems, where this plant was shown to be a good free radical scavenger. The MAO-A bioassay was also performed to detect possible antidepressant activities demonstrating that both extracts inhibited this enzyme, which has a key role in neurotransmitters metabolism. However, no activity was detected in the acetylcholinesterase and GABA assays. In general, the methanolic extract was more effective than the aqueous.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1007/s11064-009-9981-0
DO - 10.1007/s11064-009-9981-0
M3 - Journal article
C2 - 19760174
VL - 34
SP - 1955
EP - 1961
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 11
ER -
ID: 14856544