Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands
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Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. / Krogsgaard-Larsen, Niels; Jensen, Anders A.; Kehler, Jan.
I: Bioorganic & Medicinal Chemistry Letters, Bind 20, Nr. 18, 15.09.2010, s. 5431-5433.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands
AU - Krogsgaard-Larsen, Niels
AU - Jensen, Anders A.
AU - Kehler, Jan
N1 - Keywords: carbene, C-H insertion, serotonin, 5-HT2C, 5-HT6, 1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole
PY - 2010/9/15
Y1 - 2010/9/15
N2 - Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
AB - Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
KW - Cell Line
KW - Hela Cells
KW - Humans
KW - Indoles
KW - Ligands
KW - Protein Binding
KW - Pyrazines
KW - Receptor, Serotonin, 5-HT2C
KW - Receptors, Serotonin
KW - Structure-Activity Relationship
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1016/j.bmcl.2010.07.105
DO - 10.1016/j.bmcl.2010.07.105
M3 - Journal article
C2 - 20719507
VL - 20
SP - 5431
EP - 5433
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
SN - 0960-894X
IS - 18
ER -
ID: 34207860