Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium
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Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium. / Jäger, Anna Katharina; Krydsfeldt, Katrine; Rasmussen, Hasse Bonde.
I: Phytotherapy Research, Bind 23, Nr. 11, 2009, s. 1642-1644.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium
AU - Jäger, Anna Katharina
AU - Krydsfeldt, Katrine
AU - Rasmussen, Hasse Bonde
N1 - Keywords: apigenin; benzodiazepine site; GABA; Tanacetum parthenium
PY - 2009
Y1 - 2009
N2 - Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.
AB - Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1002/ptr.2816
DO - 10.1002/ptr.2816
M3 - Journal article
C2 - 19441011
VL - 23
SP - 1642
EP - 1644
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 11
ER -
ID: 14148302