Selected pharmacokinetic parameters for cefovecin in hens and green iguanas
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Selected pharmacokinetic parameters for cefovecin in hens and green iguanas. / Thuesen, Line Risager; Bertelsen, Mads Frost; Brimer, Leon; Skaanild, Mette Tingleff.
I: Journal of Veterinary Pharmacology and Therapeutics, Bind 32, Nr. 6, 2009, s. 613-617.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Selected pharmacokinetic parameters for cefovecin in hens and green iguanas
AU - Thuesen, Line Risager
AU - Bertelsen, Mads Frost
AU - Brimer, Leon
AU - Skaanild, Mette Tingleff
PY - 2009
Y1 - 2009
N2 - The third generation cephalosporin cefovecin has been shown to have an exceptionally long elimination half-life in dogs and cats, making it suitable for antibacterial treatment with a 14-day dosing interval in these species. Pharmacokinetic parameters for cefovecin were investigated in juvenile hens and green iguanas, following subcutaneous injections with 10 mg cefovecin / kg bodyweight. Preliminary studies in eight additional species of birds and reptiles were performed and results were compared with the parameters found in hens and green iguanas. The kinetics were characterized by rapid absorption with peak plasma concentration of 6 ± 2 lg / mL in hens and 35 ± 12 lg / mL in green iguanas. The mean plasma half-life for cefovecin was 0.9 ± 0.3 h for hens and 3.9 h in green iguanas. Volume of distribution was 1.6 ± 0.5 L / kg for hens and 0.3 L / kg for green iguanas and clearance was 1252 ± 185 mLÆh/ kg for hens and 53 mLÆh/ kg for green iguanas. Results from preliminary studies did not differ notably from those seen in hens and green iguanas. Cefovecin is not suitable for the treatment of bacterial infections with a 14-day dosing interval in hens or green iguanas and seems not to be in a number of other bird and retile species either.
AB - The third generation cephalosporin cefovecin has been shown to have an exceptionally long elimination half-life in dogs and cats, making it suitable for antibacterial treatment with a 14-day dosing interval in these species. Pharmacokinetic parameters for cefovecin were investigated in juvenile hens and green iguanas, following subcutaneous injections with 10 mg cefovecin / kg bodyweight. Preliminary studies in eight additional species of birds and reptiles were performed and results were compared with the parameters found in hens and green iguanas. The kinetics were characterized by rapid absorption with peak plasma concentration of 6 ± 2 lg / mL in hens and 35 ± 12 lg / mL in green iguanas. The mean plasma half-life for cefovecin was 0.9 ± 0.3 h for hens and 3.9 h in green iguanas. Volume of distribution was 1.6 ± 0.5 L / kg for hens and 0.3 L / kg for green iguanas and clearance was 1252 ± 185 mLÆh/ kg for hens and 53 mLÆh/ kg for green iguanas. Results from preliminary studies did not differ notably from those seen in hens and green iguanas. Cefovecin is not suitable for the treatment of bacterial infections with a 14-day dosing interval in hens or green iguanas and seems not to be in a number of other bird and retile species either.
KW - Former LIFE faculty
U2 - 10.1111/j.1365-2885.2009.01083.x
DO - 10.1111/j.1365-2885.2009.01083.x
M3 - Journal article
C2 - 20444017
VL - 32
SP - 613
EP - 617
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 6
ER -
ID: 16131525