To study the high-transition dense-gas tracers and their relationships to the star formation of the inner similar to 2 kpc circumnuclear region of NGC 253, we present HCN J = 4-3 and HCO+ J = 4-3 maps obtained with the James Clerk Maxwell Telescope. Using the spatially resolved data, we compute the concentration indices r(90)/r(50) for the different tracers. HCN and HCO+ 4-3 emission features tend to be centrally concentrated, which is in contrast to the shallower distribution of CO 1-0 and the stellar component. The dense-gas fraction (f(dense), traced by v the velocity-integrated-intensity ratios of HCN/CO and HCO+/CO) and the ratio R-31 (CO 3-2 / 1 -0) decline towards larger galactocentric distances, but increase with higher star formation rate surface density. The radial variation and the large scatter of f(dense )- dense and R31 imply distinct physical conditions in different regions of the galactic disc. The relationships of f(dense) versus Sigma(stellar) and SFEdense versus Sigma(stellar) are explored. SFEdense increases with higher Sigma(stellar) in this galaxy, which is inconsistent with previous work that used HCN 1-0 data. This implies that existing stellar components might have different effects on the high-J HCN and HCO+ than their low-J emission. We also find that SFE(dense )seems to be decreasing with higher f(dense) which is consistent with previous works, and it suggests that the ability of the dense gas to form stars diminishes when the average density of the gas increases. This is expected in a scenario where only the regions with high-density contrast collapse and form stars.