Bibliografisk note

Funding Information:
This work and the CHARGE-TOPMed (Cohorts for Heart and Aging Research in Genomic Epidemiology-Trans-Omics for Precision Medicine) Hemostasis Working Group was funded in part by the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) grant numbers R01 HL134894 and R01 HL139553 . Infrastructure for the CHARGE consortium was supported by NIH/NHLBI grant number R01HL105756. The Analysis Commons was funded by NIH/NHBLI grant number R01 HL131136. PR was supported by the American Heart Association and the DC Women's Board (23POST1021300). C.J.L. was supported by NIH/NHLBI grant number R33 HL141791 and the Michel Mirowski M.D. Professorship in Cardiology. C.H. and J.F.W. were supported by the UK Medical Research Council grant U. MC_UU_00007/10. G.T.-S. is supported by the Pla Estratègic de Recerca i Innovació en Salut grant from the Catalan Department of Health ( SLT017/20/000100 ). M.S.-L is supported by a Miguel Servet contract from the Instituto de Salud Carlos III Spanish Health Institute (CPII22/00007) and cofinanced by the European Social Fund. L.M.R. was supported by the National Center for Advancing Translational Sciences, National Institutes of Health , through grant KL2TR002490 . Molecular data for the TOPMed program was supported by the NIH/ NHLBI . Core support including centralized genomic read mapping and genotype calling, along with variant quality metrics and filtering were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Core support including phenotype harmonization, data management, sample-identity QC, and general program coordination were provided by the TOPMed Data Coordinating Center (R01HL-120393; U01HL-120393; contract HHSN268201800001I). The study-specific omics support information is provided in the TOPMed Omics Support Table ( supplemental Table 15 ). Further study-specific funding and acknowledgments are detailed in the supplemental Methods .

Funding Information:
The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the NHLBI, the National Institutes of Health, or the US Department of Health and Human Services.The authors thank the CARDIoGRAMplusC4D and MEGASTROKE consortium investigators for making their summary statistics publicly available, as well as the MVP study investigators for making their summary statistics available through dbGaP (database of Genotypes and Phenotypes). The authors also acknowledge the participants and staff of the contributing studies. This work and the CHARGE-TOPMed (Cohorts for Heart and Aging Research in Genomic Epidemiology-Trans-Omics for Precision Medicine) Hemostasis Working Group was funded in part by the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) grant numbers R01 HL134894 and R01 HL139553. Infrastructure for the CHARGE consortium was supported by NIH/NHLBI grant number R01HL105756. The Analysis Commons was funded by NIH/NHBLI grant number R01 HL131136. PR was supported by the American Heart Association and the DC Women's Board (23POST1021300). C.J.L. was supported by NIH/NHLBI grant number R33 HL141791 and the Michel Mirowski M.D. Professorship in Cardiology. C.H. and J.F.W. were supported by the UK Medical Research Council grant U. MC_UU_00007/10. G.T.-S. is supported by the Pla Estratègic de Recerca i Innovació en Salut grant from the Catalan Department of Health (SLT017/20/000100). M.S.-L is supported by a Miguel Servet contract from the Instituto de Salud Carlos III Spanish Health Institute (CPII22/00007) and cofinanced by the European Social Fund. L.M.R. was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant KL2TR002490. Molecular data for the TOPMed program was supported by the NIH/NHLBI. Core support including centralized genomic read mapping and genotype calling, along with variant quality metrics and filtering were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Core support including phenotype harmonization, data management, sample-identity QC, and general program coordination were provided by the TOPMed Data Coordinating Center (R01HL-120393; U01HL-120393; contract HHSN268201800001I). The study-specific omics support information is provided in the TOPMed Omics Support Table (supplemental Table 15). Further study-specific funding and acknowledgments are detailed in the supplemental Methods. Contribution: A.C.M. A.P.R. A.L. A. Beswick, A.D.J. A.v.H.V. B.D.M. B.M.P. C.H. D.J.S. D.-A.T. D.O.M.-K. F.R.R. H.C. I.R. J.W.J. J.F.W. J.-F.D. J.I.R. J.E.C. J.B. J.M.S. J.P.L. J.C.S. K.C.D. K.D.T. L.M.R. L.A. L.C. Becker, L.A.L. L.C. Brody, L.E. M.F.D. M.A.I. M.-H.C. M.F. N.F. N.L.S. O.P. P.-E.M. R.A.M. S.R.C. S.S.R. T.E.H. W.M. and Y.B.-S. contributed to the design and/or funding of the included studies from the TOPMed program and/or CHARGE consortium; A.C.M. A.P.R. A.L. A. Beswick, A.D.J. A.M.-P. A.v.H.V. A.B.O. B.A.T.R. B.D.M. B.M.P. C.H. D.J.S. D.-A.T. D.J. D.O.M.-K. F.v.R. F.R.R. G.D. G.D.C. I.R. I.K. J.W.J. J.F.W. J.-F.D. J.R.O. J.E.H. J.E.C. J.B. J.P.L. J.C.S. K.C.D. K.A.R. K.D.T. L.A. L.C. Brody, L.R.Y. M.E.K. M.S.-L. M.R.B. M.-H.C. M.P.M.d.M. M.F. N.P. N.F. N.-Q.L. O.P. P.S.d.V. P.S. P.-E.M. P.v.d.H. R.A.M. R.L.G. S.E.H. S.R.C. S.T. T.H.E. T.H. T.O.K. and Y.B.-S. contributed to the acquisition of genotype and/or phenotype data; A.S.H. A.C.M. A. Bebo, A.D.J. A.M.-P. A.P.M. A.B.O. B.A.T.R. B.D.M. C.H. D.-A.T. D.J. F.T. G.D. G.T.S. G.D.C. G.E.D. J.F.D. J.R.O.C. J.E.H. J.A.B. J.Y. J.P.L. K.C.D. K.A.R. L.M.R. L.R.Y. L.K. M.E.K. M.S.-L. M.R.B. M.-H.C. M.G. N.-Q.L. N.L.S. P.S.d.V. P.K.J. R.A.M. R.N. R.E.M. R.L.G. S.T. T.M.B. and X.G. contributed to the genetic epidemiology analyses and interpretation; C.J.L. M.A. P.R. and W.O.O. contributed to the design of the gene silencing experiments; P.R. performed the gene silencing experiments; P.R. and C.J.L. contributed to data analysis and interpretation of the gene silencing experiments; A.S.H. A.C.M. C.J.L. M.R.B. M.S.-L. N.L.S. P.R. P.S.d.V. drafted the initial manuscript; and all coauthors participated in critical review of the manuscript.

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