TY - JOUR

T1 - Long-term effects of toluene inhalation on rat behavior

AU - Forkman, B. A.

AU - Ljungberg, T.

AU - Johnson, A. C.

AU - Nylén, P.

AU - Ståhle, L.

AU - Höglund, G.

AU - Ungerstedt, U.

PY - 1991

Y1 - 1991

N2 - The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were made 11 to 35 days after the end of the exposure. The results indicate that toluene exposure causes a long-lasting impairment on the extinction process and reduction in the variability of the baseline response in the operant behavior situation. Toluene also had an effect on the water regulation.

AB - The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were made 11 to 35 days after the end of the exposure. The results indicate that toluene exposure causes a long-lasting impairment on the extinction process and reduction in the variability of the baseline response in the operant behavior situation. Toluene also had an effect on the water regulation.

KW - Conditioning

KW - Exploration

KW - Extinction

KW - Long-term effect

KW - Long-term exposure

KW - Rat

KW - Solvents

KW - Toluene

KW - Water loss

UR - http://www.scopus.com/inward/record.url?scp=0025939478&partnerID=8YFLogxK

U2 - 10.1016/0892-0362(91)90052-X

DO - 10.1016/0892-0362(91)90052-X

M3 - Journal article

C2 - 1758400

AN - SCOPUS:0025939478

VL - 13

SP - 475

EP - 481

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 5

ER -