Nanocarriers of antigen proteins for vaccine delivery
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Nanocarriers of antigen proteins for vaccine delivery. / Lopes Chaves, Luíse; Dourado, Douglas; Prunache, Ioana-Bianca; Manuelle Marques da Silva, Paloma; Tacyana Dos Santos Lucena, Gislayne; Cardoso de Souza, Zilyane; Muniz Mendes Freire de Moura, Patrícia; Nunes Bordallo, Heloísa; Rocha Formiga, Fabio; de Souza Rebouças, Juliana.
I: International Journal of Pharmaceutics, Bind 659, 124162, 25.06.2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Nanocarriers of antigen proteins for vaccine delivery
AU - Lopes Chaves, Luíse
AU - Dourado, Douglas
AU - Prunache, Ioana-Bianca
AU - Manuelle Marques da Silva, Paloma
AU - Tacyana Dos Santos Lucena, Gislayne
AU - Cardoso de Souza, Zilyane
AU - Muniz Mendes Freire de Moura, Patrícia
AU - Nunes Bordallo, Heloísa
AU - Rocha Formiga, Fabio
AU - de Souza Rebouças, Juliana
N1 - Copyright © 2024. Published by Elsevier B.V.
PY - 2024/6/25
Y1 - 2024/6/25
N2 - Nanoformulations in vaccinology provide antigen stability and enhanced immunogenicity, in addition to providing targeted delivery and controlled release. In the last years, much research has been focused on vaccine development using virus-like particles, liposomes, emulsions, polymeric, lipid, and inorganic nanoparticles. Importantly, nanoparticle interactions with innate and adaptive immune systems must be clearly understood to guide the rational development of nanovaccines. This review provides a recap and updates on different aspects advocating nanoparticles as promising antigen carriers and immune cell activators for vaccination. Moreover, it offers a discussion of how the physicochemical properties of nanoparticles are modified to target specific cells and improve vaccine efficacy.
AB - Nanoformulations in vaccinology provide antigen stability and enhanced immunogenicity, in addition to providing targeted delivery and controlled release. In the last years, much research has been focused on vaccine development using virus-like particles, liposomes, emulsions, polymeric, lipid, and inorganic nanoparticles. Importantly, nanoparticle interactions with innate and adaptive immune systems must be clearly understood to guide the rational development of nanovaccines. This review provides a recap and updates on different aspects advocating nanoparticles as promising antigen carriers and immune cell activators for vaccination. Moreover, it offers a discussion of how the physicochemical properties of nanoparticles are modified to target specific cells and improve vaccine efficacy.
KW - Humans
KW - Vaccines/administration & dosage
KW - Animals
KW - Nanoparticles
KW - Antigens/administration & dosage
KW - Drug Carriers/chemistry
KW - Drug Delivery Systems/methods
KW - Nanoparticle Drug Delivery System/chemistry
U2 - 10.1016/j.ijpharm.2024.124162
DO - 10.1016/j.ijpharm.2024.124162
M3 - Review
C2 - 38663646
VL - 659
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
M1 - 124162
ER -
ID: 397936116