Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance. The Inter99 Study
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Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance. The Inter99 Study. / Lau, C.; Færch, K.; Glümer, C.; Tetens, I.; Pedersen, O.; Carstensen, B.; Jørgensen, T.; Borch-Johnsen, K.
I: Diabetes Care, Bind 28, Nr. 6, 2005, s. 1397-1403.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance. The Inter99 Study
AU - Lau, C.
AU - Færch, K.
AU - Glümer, C.
AU - Tetens, I.
AU - Pedersen, O.
AU - Carstensen, B.
AU - Jørgensen, T.
AU - Borch-Johnsen, K.
N1 - Obs! Selve artiklen har intet DOI-nr., så det registrerede DOI linker alene til en senere publiceret rettelse til artiklen...
PY - 2005
Y1 - 2005
N2 - To examine the relationship between daily glycemic index, daily glycemic load, simple sugars, dietary fiber, and the prevalence of a measure of insulin resistance in 30- to 60-year-old nondiabetic Danish men and women. The Inter99 study is a nonpharmacological intervention study. We used baseline data and examined cross-sectional associations between carbohydrate-related dietary factors and an estimate of insulin resistance in 5,675 subjects at 30-60 years. The dietary intake was estimated from a self-administered food frequency questionnaire, and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity, total energy intake, BMI, and waist circumference. Intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0.05). Intake of dietary fiber explained the associations with daily glycemic load and total carbohydrate and attenuated the association with fruit and vegetables. No significant associations were observed for daily glycemie index or sucrose. Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance. Furthermore, intake of dietary fiber was inversely associated with the probability of having insulin resistance.
AB - To examine the relationship between daily glycemic index, daily glycemic load, simple sugars, dietary fiber, and the prevalence of a measure of insulin resistance in 30- to 60-year-old nondiabetic Danish men and women. The Inter99 study is a nonpharmacological intervention study. We used baseline data and examined cross-sectional associations between carbohydrate-related dietary factors and an estimate of insulin resistance in 5,675 subjects at 30-60 years. The dietary intake was estimated from a self-administered food frequency questionnaire, and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity, total energy intake, BMI, and waist circumference. Intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0.05). Intake of dietary fiber explained the associations with daily glycemic load and total carbohydrate and attenuated the association with fruit and vegetables. No significant associations were observed for daily glycemie index or sucrose. Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance. Furthermore, intake of dietary fiber was inversely associated with the probability of having insulin resistance.
KW - Faculty of Science
KW - Hypoglycemia
KW - Glucose
KW - Insulin
KW - Dietary fiber
U2 - 10.2337/diacare.28.9.2340
DO - 10.2337/diacare.28.9.2340
M3 - Journal article
VL - 28
SP - 1397
EP - 1403
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 6
ER -
ID: 7950022