Effects of high dairy protein intake and vitamin D supplementation on body composition and cardiometabolic markers in 6-8-y-old children - the D-pro trial
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Effects of high dairy protein intake and vitamin D supplementation on body composition and cardiometabolic markers in 6-8-y-old children - the D-pro trial. / Thams, Line; Stounbjerg, Nanna Groth; Hvid, Lars G; Mølgaard, Christian; Hansen, Mette; Damsgaard, Camilla Trab.
I: American Journal of Clinical Nutrition, Bind 115, Nr. 4, 2022, s. 1080-1091.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of high dairy protein intake and vitamin D supplementation on body composition and cardiometabolic markers in 6-8-y-old children - the D-pro trial
AU - Thams, Line
AU - Stounbjerg, Nanna Groth
AU - Hvid, Lars G
AU - Mølgaard, Christian
AU - Hansen, Mette
AU - Damsgaard, Camilla Trab
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.
PY - 2022
Y1 - 2022
N2 - Background: Increasing evidence suggests that prevention of lifestyle diseases should begin early. Dairy protein and vitamin D can affect body composition and cardiometabolic markers, yet evidence among well-nourished children is sparse.Objectives: We investigated combined and separate effects of high dairy protein intake and vitamin D on body composition and cardiometabolic markers in children.Methods: In a 2 × 2-factorial, randomized trial, 200 white, Danish, 6-8-y-old children substituted 260 g/d dairy in their diet with high-protein (HP, 10 g protein/100 g) or normal-protein (NP, 3.5 g protein/100 g) yogurt and received blinded tablets with 20 µg/d vitamin D3 or placebo for 24 weeks during winter. We measured body composition by dual-energy X-ray absorptiometry, blood pressure, and fasting blood glucose, insulin, C-peptide, and lipids.Results: In total, 184 children (92%) completed the study. Baseline median [25th-75th percentile] dairy protein intake was 3.7 [2.5-5.1] E% and increased to 7.2 [4.7-8.8] E% and 4.2 [3.1-5.3] E% with HP and NP. Mean ± SD serum 25-hydroxyvitamin D changed from 81±17 nmol/L to 89±18 nmol/L and 48±13 nmol/L with vitamin D and placebo. There were no combined effects of dairy protein and vitamin D, except for plasma glucose, with the largest increase in the NP-vitamin D group (Pinteraction = 0.005). There were smaller increases in fat mass index (P = 0.04) with HP than NP, and the same pattern was seen for insulin, HOMA-IR, and C-peptide (all P = 0.06). LDL cholesterol was reduced with vitamin D compared to placebo (P < 0.05). Fat free mass and blood pressure were unaffected.Conclusions: High compared to normal dairy protein intake hampered an increase in fat mass index. Vitamin D supplementation counteracted the winter decline in 25-hydroxyvitamin D and the increase in LDL cholesterol observed with placebo. This study adds to the sparse evidence on dairy protein in well-nourished children and supports a vitamin D intake of ∼20 µg/d during winter.
AB - Background: Increasing evidence suggests that prevention of lifestyle diseases should begin early. Dairy protein and vitamin D can affect body composition and cardiometabolic markers, yet evidence among well-nourished children is sparse.Objectives: We investigated combined and separate effects of high dairy protein intake and vitamin D on body composition and cardiometabolic markers in children.Methods: In a 2 × 2-factorial, randomized trial, 200 white, Danish, 6-8-y-old children substituted 260 g/d dairy in their diet with high-protein (HP, 10 g protein/100 g) or normal-protein (NP, 3.5 g protein/100 g) yogurt and received blinded tablets with 20 µg/d vitamin D3 or placebo for 24 weeks during winter. We measured body composition by dual-energy X-ray absorptiometry, blood pressure, and fasting blood glucose, insulin, C-peptide, and lipids.Results: In total, 184 children (92%) completed the study. Baseline median [25th-75th percentile] dairy protein intake was 3.7 [2.5-5.1] E% and increased to 7.2 [4.7-8.8] E% and 4.2 [3.1-5.3] E% with HP and NP. Mean ± SD serum 25-hydroxyvitamin D changed from 81±17 nmol/L to 89±18 nmol/L and 48±13 nmol/L with vitamin D and placebo. There were no combined effects of dairy protein and vitamin D, except for plasma glucose, with the largest increase in the NP-vitamin D group (Pinteraction = 0.005). There were smaller increases in fat mass index (P = 0.04) with HP than NP, and the same pattern was seen for insulin, HOMA-IR, and C-peptide (all P = 0.06). LDL cholesterol was reduced with vitamin D compared to placebo (P < 0.05). Fat free mass and blood pressure were unaffected.Conclusions: High compared to normal dairy protein intake hampered an increase in fat mass index. Vitamin D supplementation counteracted the winter decline in 25-hydroxyvitamin D and the increase in LDL cholesterol observed with placebo. This study adds to the sparse evidence on dairy protein in well-nourished children and supports a vitamin D intake of ∼20 µg/d during winter.
KW - Faculty of Science
KW - Pediatric
KW - Cholecalciferol
KW - DXA
KW - BMI
KW - FMI
KW - FFMI
KW - Cholesterol
KW - Blood lipids
KW - Cardiovascular
KW - Milk protein
U2 - 10.1093/ajcn/nqab424
DO - 10.1093/ajcn/nqab424
M3 - Journal article
C2 - 35015806
VL - 115
SP - 1080
EP - 1091
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 289308914