Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes
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Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes. / Proschowsky, Helle Friis; Fredholm, Merete.
I: Animal Genetics, Bind 38, Nr. 2, 2007, s. 171-173.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes
AU - Proschowsky, Helle Friis
AU - Fredholm, Merete
PY - 2007
Y1 - 2007
N2 - Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.
AB - Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.
KW - Former LIFE faculty
KW - canine
KW - cholecystokinin
KW - Eurasian dog
KW - exocrine pancreaTIC insufficiency
KW - inheritance
KW - segregation
U2 - 10.1111/j.1365-2052.2007.01570.x
DO - 10.1111/j.1365-2052.2007.01570.x
M3 - Journal article
C2 - 17302791
VL - 38
SP - 171
EP - 173
JO - Animal Genetics
JF - Animal Genetics
SN - 0268-9146
IS - 2
ER -
ID: 8073255