Neuroprotective and neurochemical properties of mint extracts
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Neuroprotective and neurochemical properties of mint extracts. / López, Víctor; Martín, Sara; Gómez-Serranillos, Maria Pilar; Carretero, Maria Emilia; Jäger, Anna Katharina; Calvo, Maria Isabel.
I: Phytotherapy Research, Bind 24, Nr. 6, 2010, s. 869-874.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neuroprotective and neurochemical properties of mint extracts
AU - López, Víctor
AU - Martín, Sara
AU - Gómez-Serranillos, Maria Pilar
AU - Carretero, Maria Emilia
AU - Jäger, Anna Katharina
AU - Calvo, Maria Isabel
N1 - Keywords: Mentha; Traditional medicine; PC12; antioxidant; MAO-A; GABAA
PY - 2010
Y1 - 2010
N2 - Mints are aromatic plants with a tradition as medicinal remedies and culinary herbs. With the aim of investigating potential central nervous system (CNS) activities of traditional medicinal plants, four species and one hybrid of the genus Mentha (M. aquatica, M. longifolia, M. pulegium, M. suaveolens and M. x piperita) were selected. Methanolic extracts of the plants were tested for protective effects against hydrogen-peroxide-induced toxicity in PC12 cells, antioxidant activity (by ABTS and X/XO methods) and neurochemical properties (MAO-A inhibition, AChE inhibition and affinity to the GABA(A) receptor). Mentha x piperita and Mentha aquatica produced significant (p < 0.05) protection of the PC12 cells against oxidative stress. All the plants exhibited antioxidant and MAO-A inhibitory activities, M. x piperita being the most active. M. aquatica showed the highest affinity to the GABA(A)-receptor assay. Results demonstrate that mints might have effect on the CNS. Copyright (c) 2009 John Wiley & Sons, Ltd.
AB - Mints are aromatic plants with a tradition as medicinal remedies and culinary herbs. With the aim of investigating potential central nervous system (CNS) activities of traditional medicinal plants, four species and one hybrid of the genus Mentha (M. aquatica, M. longifolia, M. pulegium, M. suaveolens and M. x piperita) were selected. Methanolic extracts of the plants were tested for protective effects against hydrogen-peroxide-induced toxicity in PC12 cells, antioxidant activity (by ABTS and X/XO methods) and neurochemical properties (MAO-A inhibition, AChE inhibition and affinity to the GABA(A) receptor). Mentha x piperita and Mentha aquatica produced significant (p < 0.05) protection of the PC12 cells against oxidative stress. All the plants exhibited antioxidant and MAO-A inhibitory activities, M. x piperita being the most active. M. aquatica showed the highest affinity to the GABA(A)-receptor assay. Results demonstrate that mints might have effect on the CNS. Copyright (c) 2009 John Wiley & Sons, Ltd.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1002/ptr.3037
DO - 10.1002/ptr.3037
M3 - Journal article
C2 - 19943334
VL - 24
SP - 869
EP - 874
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 6
ER -
ID: 19844931