The uremic environment and muscle dysfunction in man and rat
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The uremic environment and muscle dysfunction in man and rat. / Harrison, Adrian Paul; Nielsen, Arne Høj; Eidemak, I.; Molsted, S.; Bartels, E.M.
I: NEPHRON PHYSIOLOGY, Bind 103, Nr. 1, 2006, s. 33-42.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The uremic environment and muscle dysfunction in man and rat
AU - Harrison, Adrian Paul
AU - Nielsen, Arne Høj
AU - Eidemak, I.
AU - Molsted, S.
AU - Bartels, E.M.
PY - 2006
Y1 - 2006
N2 - Background: Patients reaching end-stage renal disease experience debilitating fatigue, with progression of this disease, rendering patients dysfunctional in their everyday lives. Methods: In vivo measurements of muscle function, assessed using surface electromyography (EMG), were made on 25 patients prior to and after a session of hemodialysis (HD) treatment, alongside in vitro measurements of muscle function in isolated rat muscles incubated in normal or uremic conditions approximating to those found in uremic rats (rat uremic: RU) or uremic humans (human uremic: HU). Results: HD significantly affected plasma values, e.g. reducing urea (69%), creatinine (62%), potassium (23%) and phosphate (48%) concentrations in patients (all p<0.01). Treatment also improved the EMG frequency of 2nd dorsal interosseous (fast-twitch) (p<0.01), although no change was noted for vastus lateralis (slow-twitch). In isolated rat muscles, a uremic environment had no significant effect on slow-twitch soleus during field stimulation, however, in fast-twitch extensor digitorum longus, a significant 23% (RU) and 22% (HU) faster rate of decline in force was measured, compared to controls (p<0.001 and p<0.01, respectively). Conclusion: It is concluded that (1) muscle weakness and its electrophysiological correlates may be rapidly induced by uremic solutes and rapidly reversed when the solutes are removed by dialysis, and (2) fast-twitch muscles are more readily affected by uremic conditions than slow-twitch muscles.
AB - Background: Patients reaching end-stage renal disease experience debilitating fatigue, with progression of this disease, rendering patients dysfunctional in their everyday lives. Methods: In vivo measurements of muscle function, assessed using surface electromyography (EMG), were made on 25 patients prior to and after a session of hemodialysis (HD) treatment, alongside in vitro measurements of muscle function in isolated rat muscles incubated in normal or uremic conditions approximating to those found in uremic rats (rat uremic: RU) or uremic humans (human uremic: HU). Results: HD significantly affected plasma values, e.g. reducing urea (69%), creatinine (62%), potassium (23%) and phosphate (48%) concentrations in patients (all p<0.01). Treatment also improved the EMG frequency of 2nd dorsal interosseous (fast-twitch) (p<0.01), although no change was noted for vastus lateralis (slow-twitch). In isolated rat muscles, a uremic environment had no significant effect on slow-twitch soleus during field stimulation, however, in fast-twitch extensor digitorum longus, a significant 23% (RU) and 22% (HU) faster rate of decline in force was measured, compared to controls (p<0.001 and p<0.01, respectively). Conclusion: It is concluded that (1) muscle weakness and its electrophysiological correlates may be rapidly induced by uremic solutes and rapidly reversed when the solutes are removed by dialysis, and (2) fast-twitch muscles are more readily affected by uremic conditions than slow-twitch muscles.
KW - Former LIFE faculty
KW - Uremia
KW - Muscle dysfunction
KW - Dyalysis
KW - Electromyography
KW - Muscle strength
U2 - 10.1159/000090221
DO - 10.1159/000090221
M3 - Journal article
C2 - 16352915
VL - 103
SP - 33
EP - 42
JO - Nephron - Clinical Practice
JF - Nephron - Clinical Practice
SN - 1660-8151
IS - 1
ER -
ID: 8013598