Analysing the distribution of synaptic vesicles using a spatial point process model
Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
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Analysing the distribution of synaptic vesicles using a spatial point process model. / Khanmohammadi, Mahdieh; Waagepetersen, Rasmus; Nava, Nicoletta; Nyengaard, Jens; Sporring, Jon.
Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. Association for Computing Machinery, 2014. s. 73-78.Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
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TY - GEN
T1 - Analysing the distribution of synaptic vesicles using a spatial point process model
AU - Khanmohammadi, Mahdieh
AU - Waagepetersen, Rasmus
AU - Nava, Nicoletta
AU - Nyengaard, Jens
AU - Sporring, Jon
N1 - Conference code: 5
PY - 2014
Y1 - 2014
N2 - Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.
AB - Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.
KW - Faculty of Health and Medical Sciences
KW - Synaptic vesicles distribution,
KW - Spatial point process
KW - Serial section transmission electron microscopy images,
KW - Stress
U2 - 10.1145/2649387.2649404
DO - 10.1145/2649387.2649404
M3 - Article in proceedings
SP - 73
EP - 78
BT - Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
PB - Association for Computing Machinery
Y2 - 20 September 2014 through 23 September 2014
ER -
ID: 159741105