Does vitamin C deficiency affect cognitive development and function?
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Does vitamin C deficiency affect cognitive development and function? / Hansen, Stine Normann; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens.
I: Nutrients, Bind 6, Nr. 9, 2014, s. 3818-3846.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Does vitamin C deficiency affect cognitive development and function?
AU - Hansen, Stine Normann
AU - Tveden-Nyborg, Pernille
AU - Lykkesfeldt, Jens
PY - 2014
Y1 - 2014
N2 - Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
AB - Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
KW - Faculty of Health and Medical Sciences
KW - vitamin C
KW - cognition
KW - oxidative stress
KW - ROS
KW - aging
KW - development
KW - stroke
U2 - 10.3390/nu6093818
DO - 10.3390/nu6093818
M3 - Journal article
C2 - 25244370
VL - 6
SP - 3818
EP - 3846
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 9
ER -
ID: 124426815