HIV and metabolic syndrome in an Ethiopian population
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
HIV and metabolic syndrome in an Ethiopian population. / Møller, Sanne Pagh; Amare, Hiwot; Christensen, Dirk Lund; Yilma, Daniel; Abdissa, Alemseged; Friis, Henrik; Faurholt-Jepsen, Daniel; Olsen, Mette Frahm.
I: Annals of Human Biology, Bind 47, Nr. 5, 20.07.2020, s. 457-464.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - HIV and metabolic syndrome in an Ethiopian population
AU - Møller, Sanne Pagh
AU - Amare, Hiwot
AU - Christensen, Dirk Lund
AU - Yilma, Daniel
AU - Abdissa, Alemseged
AU - Friis, Henrik
AU - Faurholt-Jepsen, Daniel
AU - Olsen, Mette Frahm
N1 - CURIS 2020 NEXS 215
PY - 2020/7/20
Y1 - 2020/7/20
N2 - Background: The global prevalence of metabolic syndrome (MS) is increasing due to lifestyle changes. Studies have found that MS is associated with human immunodeficiency virus (HIV) and antiretroviral treatment (ART), but controversies still exist on associations between HIV and MS.Aims: To assess associations between HIV and MS among ART-naïve HIV positive individuals compared to HIV negative individuals.Subjects and methods: A cross-sectional study among ART-naïve HIV positive and HIV negative individuals recruited from HIV treatment and testing facilities in Ethiopia. Information was collected on components of MS: waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure and fasting plasma glucose (FPG). Data were analysed using logistic and linear regression stratified by sex and adjusted for age, wealth and education.Results: Data from 329 HIV positive and 100 HIV negative individuals were included. HIV positive status was associated with higher odds of MS in women (OR: 3.56, 95%CI: 1.25; 10.15) (n = 292), but not in men (OR: 0.98, 95%CI: 0.22; 4.30) (n = 137), interaction: p= .11. Associations between HIV and components of MS were strongest for HDL-C among women and for FPG among men. The most prevalent components of MS in HIV positive individuals were elevated triglycerides, reduced HDL-C and elevated FPG.Conclusions: HIV was associated with MS among ART-naïve women, suggesting that MS should be evaluated before initiating ART and monitored during treatment to identify those at risk of developing diabetes and cardiovascular disease (CVD).
AB - Background: The global prevalence of metabolic syndrome (MS) is increasing due to lifestyle changes. Studies have found that MS is associated with human immunodeficiency virus (HIV) and antiretroviral treatment (ART), but controversies still exist on associations between HIV and MS.Aims: To assess associations between HIV and MS among ART-naïve HIV positive individuals compared to HIV negative individuals.Subjects and methods: A cross-sectional study among ART-naïve HIV positive and HIV negative individuals recruited from HIV treatment and testing facilities in Ethiopia. Information was collected on components of MS: waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure and fasting plasma glucose (FPG). Data were analysed using logistic and linear regression stratified by sex and adjusted for age, wealth and education.Results: Data from 329 HIV positive and 100 HIV negative individuals were included. HIV positive status was associated with higher odds of MS in women (OR: 3.56, 95%CI: 1.25; 10.15) (n = 292), but not in men (OR: 0.98, 95%CI: 0.22; 4.30) (n = 137), interaction: p= .11. Associations between HIV and components of MS were strongest for HDL-C among women and for FPG among men. The most prevalent components of MS in HIV positive individuals were elevated triglycerides, reduced HDL-C and elevated FPG.Conclusions: HIV was associated with MS among ART-naïve women, suggesting that MS should be evaluated before initiating ART and monitored during treatment to identify those at risk of developing diabetes and cardiovascular disease (CVD).
KW - Faculty of Science
KW - HIV
KW - ART-naïve
KW - Metabolic syndrome
KW - Sub-Saharan Africa
KW - Ethiopia
U2 - 10.1080/03014460.2020.1781929
DO - 10.1080/03014460.2020.1781929
M3 - Journal article
C2 - 32683894
VL - 47
SP - 457
EP - 464
JO - Annals of Human Biology
JF - Annals of Human Biology
SN - 0301-4460
IS - 5
ER -
ID: 245228914