Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake. / Draicchio, Fulvia; Behrends, Volker; Tillin, Neale A; Hurren, Nicholas M; Sylow, Lykke; Mackenzie, Richard.
I: Journal of Physiology, Bind 600, Nr. 20, 2022, s. 4393-4408.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake
AU - Draicchio, Fulvia
AU - Behrends, Volker
AU - Tillin, Neale A
AU - Hurren, Nicholas M
AU - Sylow, Lykke
AU - Mackenzie, Richard
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Whole-body euglycaemia is partly maintained by two cellular processes that encourage glucose uptake in skeletal muscle; 1) the insulin- and 2) contraction-stimulated pathways, with research suggesting convergence between these two previously separate processes. The normal structural integrity of the skeletal muscle requires an intact actin cytoskeleton as well as integrin-associated proteins, thus those structures are likely fundamental for effective glucose uptake in skeletal muscle. In contrast, excessive extracellular matrix (ECM) remodelling and integrin expression in skeletal muscle may contribute to insulin resistance owing to an increased physical barrier causing reduced nutrient and hormonal flux. This review paper explores the role of the ECM and the actin cytoskeleton in insulin- and contraction-mediated glucose uptake in skeletal muscle. This is a clinically important area of research given that defects in the structural integrity of the ECM and integrin-associated proteins may contribute to loss of muscle function and decreased glucose uptake in type 2 diabetes.
AB - Whole-body euglycaemia is partly maintained by two cellular processes that encourage glucose uptake in skeletal muscle; 1) the insulin- and 2) contraction-stimulated pathways, with research suggesting convergence between these two previously separate processes. The normal structural integrity of the skeletal muscle requires an intact actin cytoskeleton as well as integrin-associated proteins, thus those structures are likely fundamental for effective glucose uptake in skeletal muscle. In contrast, excessive extracellular matrix (ECM) remodelling and integrin expression in skeletal muscle may contribute to insulin resistance owing to an increased physical barrier causing reduced nutrient and hormonal flux. This review paper explores the role of the ECM and the actin cytoskeleton in insulin- and contraction-mediated glucose uptake in skeletal muscle. This is a clinically important area of research given that defects in the structural integrity of the ECM and integrin-associated proteins may contribute to loss of muscle function and decreased glucose uptake in type 2 diabetes.
KW - Faculty of Science
KW - Integrin
KW - ILK
KW - Rac1
KW - ECM
KW - Actin cytoskeleton
KW - Muscle contraction
KW - Insulin
KW - Insulin resistance
U2 - 10.1113/JP283039
DO - 10.1113/JP283039
M3 - Review
C2 - 36054466
VL - 600
SP - 4393
EP - 4408
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 20
ER -
ID: 318441179