Ischemic preconditioning improves microvascular endothelial function in remote vasculature by enhanced prostacyclin production
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Ischemic preconditioning improves microvascular endothelial function in remote vasculature by enhanced prostacyclin production. / Rytter, Nicolai; Carter, Howard; Piil, Peter; Sørensen, Henrik; Ehlers, Thomas; Holmegaard, Frederik; Tuxen, Christoffer; Jones, Helen; Thijssen, Dick; Gliemann, Lasse; Hellsten, Ylva.
I: Journal of the American Heart Association, Bind 9, Nr. 15, e016017, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ischemic preconditioning improves microvascular endothelial function in remote vasculature by enhanced prostacyclin production
AU - Rytter, Nicolai
AU - Carter, Howard
AU - Piil, Peter
AU - Sørensen, Henrik
AU - Ehlers, Thomas
AU - Holmegaard, Frederik
AU - Tuxen, Christoffer
AU - Jones, Helen
AU - Thijssen, Dick
AU - Gliemann, Lasse
AU - Hellsten, Ylva
N1 - CURIS 2020 NEXS 248
PY - 2020
Y1 - 2020
N2 - Background: The mechanisms underlying the effect of preconditioning on remote microvasculature remains undisclosed. The primary objective was to document the remote effect of ischemic preconditioning on microvascular function in humans. The secondary objective was to test if exercise also induces remote microvascular effects. Methods and Results: A total of 12 healthy young men and women participated in 2 experimental days in a random counterbalanced order. On one day the participants underwent 4×5 minutes of forearm ischemic preconditioning, and on the other day they completed 4×5 minutes of hand-grip exercise. On both days, catheters were placed in the brachial and femoral artery and vein for infusion of acetylcholine, sodium nitroprusside, and epoprostenol. Vascular conductance was calculated from blood flow measurements with ultrasound Doppler and arterial and venous blood pressures. Ischemic preconditioning enhanced (P<0.05) the remote vasodilator response to intra-arterial acetylcholine in the leg at 5 and 90 minutes after application. The enhanced response was associated with a 6-fold increase (P<0.05) in femoral venous plasma prostacyclin levels and with a transient increase (P<0.05) in arterial plasma levels of brain-derived neurotrophic factor and vascular endothelial growth factor. In contrast, hand-grip exercise did not influence remote microvascular function. Conclusions: These findings demonstrate that ischemic preconditioning of the forearm improves remote microvascular endothelial function and suggest that one of the underlying mechanisms is a humoral-mediated potentiation of prostacyclin formation.
AB - Background: The mechanisms underlying the effect of preconditioning on remote microvasculature remains undisclosed. The primary objective was to document the remote effect of ischemic preconditioning on microvascular function in humans. The secondary objective was to test if exercise also induces remote microvascular effects. Methods and Results: A total of 12 healthy young men and women participated in 2 experimental days in a random counterbalanced order. On one day the participants underwent 4×5 minutes of forearm ischemic preconditioning, and on the other day they completed 4×5 minutes of hand-grip exercise. On both days, catheters were placed in the brachial and femoral artery and vein for infusion of acetylcholine, sodium nitroprusside, and epoprostenol. Vascular conductance was calculated from blood flow measurements with ultrasound Doppler and arterial and venous blood pressures. Ischemic preconditioning enhanced (P<0.05) the remote vasodilator response to intra-arterial acetylcholine in the leg at 5 and 90 minutes after application. The enhanced response was associated with a 6-fold increase (P<0.05) in femoral venous plasma prostacyclin levels and with a transient increase (P<0.05) in arterial plasma levels of brain-derived neurotrophic factor and vascular endothelial growth factor. In contrast, hand-grip exercise did not influence remote microvascular function. Conclusions: These findings demonstrate that ischemic preconditioning of the forearm improves remote microvascular endothelial function and suggest that one of the underlying mechanisms is a humoral-mediated potentiation of prostacyclin formation.
KW - Faculty of Science
KW - Ischemic preconditioning
KW - Microvascular endothelial function
KW - Platelets
KW - Prostacyclin
KW - Vasodilation
U2 - 10.1161/JAHA.120.016017
DO - 10.1161/JAHA.120.016017
M3 - Journal article
C2 - 32750305
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 15
M1 - e016017
ER -
ID: 246350158