Management of hematologic malignancies in the era of COVID-19 pandemic: Pathogenetic mechanisms, impact of obesity, perspectives, and challenges
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Management of hematologic malignancies in the era of COVID-19 pandemic: Pathogenetic mechanisms, impact of obesity, perspectives, and challenges. / Tsilingiris, Dimitrios; Nasiri-Ansari, Narjes; Spyrou, Nikolaos; Magkos, Faidon; Dalamaga, Maria.
I: Cancers, Bind 14, Nr. 10, 2494, 2022.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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T1 - Management of hematologic malignancies in the era of COVID-19 pandemic: Pathogenetic mechanisms, impact of obesity, perspectives, and challenges
AU - Tsilingiris, Dimitrios
AU - Nasiri-Ansari, Narjes
AU - Spyrou, Nikolaos
AU - Magkos, Faidon
AU - Dalamaga, Maria
N1 - CURIS 2022 NEXS 137
PY - 2022
Y1 - 2022
N2 - The COVID-19 pandemic brought about an unprecedented societal and healthcare system crisis, considerably affecting healthcare workers and patients, particularly those with chronic diseases. Patients with hematologic malignancies faced a variety of challenges, pertinent to the nature of an underlying hematologic disorder itself as well as its therapy as a risk factor for severe SARS-CoV-2 infection, suboptimal vaccine efficacy and the need for uninterrupted medical observation and continued therapy. Obesity constitutes another factor which was acknowledged since the early days of the pandemic that predisposed people to severe COVID-19, and shares a likely causal link with the pathogenesis of a broad spectrum of hematologic cancers. We review here the epidemiologic and pathogenetic features that obesity and hematologic malignancies share, as well as potential mutual pathophysiological links predisposing people to a more severe SARS-CoV-2 course. Additionally, we attempt to present the existing evidence on the multi-faceted crucial challenges that had to be overcome in this diverse patient group and discuss further unresolved questions and future challenges for the management of hematologic malignancies in the era of COVID-19.
AB - The COVID-19 pandemic brought about an unprecedented societal and healthcare system crisis, considerably affecting healthcare workers and patients, particularly those with chronic diseases. Patients with hematologic malignancies faced a variety of challenges, pertinent to the nature of an underlying hematologic disorder itself as well as its therapy as a risk factor for severe SARS-CoV-2 infection, suboptimal vaccine efficacy and the need for uninterrupted medical observation and continued therapy. Obesity constitutes another factor which was acknowledged since the early days of the pandemic that predisposed people to severe COVID-19, and shares a likely causal link with the pathogenesis of a broad spectrum of hematologic cancers. We review here the epidemiologic and pathogenetic features that obesity and hematologic malignancies share, as well as potential mutual pathophysiological links predisposing people to a more severe SARS-CoV-2 course. Additionally, we attempt to present the existing evidence on the multi-faceted crucial challenges that had to be overcome in this diverse patient group and discuss further unresolved questions and future challenges for the management of hematologic malignancies in the era of COVID-19.
KW - Faculty of Science
KW - Blood cancer
KW - COVID-19
KW - Hematologic malignancy
KW - Leukemia
KW - Lymphoma
KW - Multiple myeloma
KW - Myelodysplasia
KW - Obesity
KW - SARS-CoV-2
U2 - 10.3390/cancers14102494
DO - 10.3390/cancers14102494
M3 - Review
C2 - 35626099
VL - 14
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 10
M1 - 2494
ER -
ID: 307731701