No effect of dietary fish oil supplementation on the recruitment of brown and brite adipocytes in mice or humans under thermoneutral conditions
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No effect of dietary fish oil supplementation on the recruitment of brown and brite adipocytes in mice or humans under thermoneutral conditions. / Maurer, Stefanie F; Dieckmann, Sebastian; Lund, Jens; Fromme, Tobias; Hess, Anne Lundby; Colson, Cécilia; Kjølbæk, Louise; Astrup, Arne; Gillum, Matthew Paul; Larsen, Lesli Hingstrup; Liebisch, Gerhard; Amri, Ez-Zoubir; Klingenspor, Martin.
I: Molecular Nutrition & Food Research, Bind 65, Nr. 2, 2000681, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - No effect of dietary fish oil supplementation on the recruitment of brown and brite adipocytes in mice or humans under thermoneutral conditions
AU - Maurer, Stefanie F
AU - Dieckmann, Sebastian
AU - Lund, Jens
AU - Fromme, Tobias
AU - Hess, Anne Lundby
AU - Colson, Cécilia
AU - Kjølbæk, Louise
AU - Astrup, Arne
AU - Gillum, Matthew Paul
AU - Larsen, Lesli Hingstrup
AU - Liebisch, Gerhard
AU - Amri, Ez-Zoubir
AU - Klingenspor, Martin
N1 - CURIS 2021 NEXS 034
PY - 2021
Y1 - 2021
N2 - Scope: Brown and brite adipocytes within the mammalian adipose organ provide non-shivering thermogenesis and thus, have an exceptional capacity to dissipate chemical energy as heat. Polyunsaturated fatty acids of the n3-series, abundant in fish oil, have been repeatedly demonstrated to enhance the recruitment of thermogenic capacity in these cells, consequently affecting body adiposity and glucose tolerance. We scrutinized these effects in mice housed in a thermoneutral environment and in a human dietary intervention trial.Methods and results: Mice were housed in a thermoneutral environment eliminating the superimposing effect of mild cold-exposure on thermogenic adipocyte recruitment. Dietary fish oil supplementation in two different inbred mouse strains neither affected body mass trajectory nor enhanced the recruitment of brown and brite adipocytes, both in the presence and absence of a β3 adrenoreceptor agonist imitating the effect of cold-exposure on adipocytes. In line with these findings, dietary fish oil supplementation of persons with overweight or obesity failed to recruit thermogenic adipocytes in subcutaneous adipose tissue.Conclusion: Thus, our data question the hypothesized potential of n3-polyunsaturated fatty acids as modulators of adipocyte-based thermogenesis and energy balance regulation. This article is protected by copyright. All rights reserved.
AB - Scope: Brown and brite adipocytes within the mammalian adipose organ provide non-shivering thermogenesis and thus, have an exceptional capacity to dissipate chemical energy as heat. Polyunsaturated fatty acids of the n3-series, abundant in fish oil, have been repeatedly demonstrated to enhance the recruitment of thermogenic capacity in these cells, consequently affecting body adiposity and glucose tolerance. We scrutinized these effects in mice housed in a thermoneutral environment and in a human dietary intervention trial.Methods and results: Mice were housed in a thermoneutral environment eliminating the superimposing effect of mild cold-exposure on thermogenic adipocyte recruitment. Dietary fish oil supplementation in two different inbred mouse strains neither affected body mass trajectory nor enhanced the recruitment of brown and brite adipocytes, both in the presence and absence of a β3 adrenoreceptor agonist imitating the effect of cold-exposure on adipocytes. In line with these findings, dietary fish oil supplementation of persons with overweight or obesity failed to recruit thermogenic adipocytes in subcutaneous adipose tissue.Conclusion: Thus, our data question the hypothesized potential of n3-polyunsaturated fatty acids as modulators of adipocyte-based thermogenesis and energy balance regulation. This article is protected by copyright. All rights reserved.
KW - Faculty of Science
KW - Adipose tissue
KW - Ucp1
KW - Thermogenesis
KW - PUFA
KW - n6
KW - n3
KW - Fish oil
U2 - 10.1002/mnfr.202000681
DO - 10.1002/mnfr.202000681
M3 - Journal article
C2 - 33274552
VL - 65
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
SN - 1613-4125
IS - 2
M1 - 2000681
ER -
ID: 252682628