Accretion of fat-free mass rather than fat mass in infancy is positively associated with linear growth in childhood
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Accretion of fat-free mass rather than fat mass in infancy is positively associated with linear growth in childhood. / Admassu Wossen, Bitiya; Ritz, Christian; Wells, Jonathan C K; Girma, Tsinuel; Andersen, Gregers S; Belachew, Tefera; Owino, Victor; Michaelsen, Kim F.; Abera Mengistie, Mubarek; Wibæk Christensen, Rasmus; Friis, Henrik; Kæstel, Pernille.
In: Journal of Nutrition, Vol. 148, No. 4, 01.04.2018, p. 607-615.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Accretion of fat-free mass rather than fat mass in infancy is positively associated with linear growth in childhood
AU - Admassu Wossen, Bitiya
AU - Ritz, Christian
AU - Wells, Jonathan C K
AU - Girma, Tsinuel
AU - Andersen, Gregers S
AU - Belachew, Tefera
AU - Owino, Victor
AU - Michaelsen, Kim F.
AU - Abera Mengistie, Mubarek
AU - Wibæk Christensen, Rasmus
AU - Friis, Henrik
AU - Kæstel, Pernille
N1 - CURIS 2018 NEXS 154
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied.Objective: This study examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children.Methods: In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized accretion rates were obtained by dividing FM and FFM accretion by their respective SD.Results: FFM accretion from 0 to 6 mo of age was positively associated with length at 1 y (β = 0.64; 95% CI: 0.19, 1.09; P = 0.005) and linear growth from 1 to 5 y (β = 0.63; 95% CI: 0.19, 1.07; P = 0.005). The strongest association with FFM accretion was observed at 1 y. The association with linear growth from 1 to 5 y was mainly engendered by the 1-y association. FM accretion from 0 to 4 mo was positively associated with linear growth from 1 to 5 y (β = 0.45; 95% CI: 0.02, 0.88; P = 0.038) in the fully adjusted model.Conclusions: In Ethiopian children, FFM accretion was associated with linear growth at 1 y and no clear additional longitudinal effect from 1 to 5 y was observed. FM accretion showed a weak association from 1 to 5 y. This trial was registered at www.controlled-trials.com as ISRCTN46718296.
AB - Background: We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied.Objective: This study examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children.Methods: In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized accretion rates were obtained by dividing FM and FFM accretion by their respective SD.Results: FFM accretion from 0 to 6 mo of age was positively associated with length at 1 y (β = 0.64; 95% CI: 0.19, 1.09; P = 0.005) and linear growth from 1 to 5 y (β = 0.63; 95% CI: 0.19, 1.07; P = 0.005). The strongest association with FFM accretion was observed at 1 y. The association with linear growth from 1 to 5 y was mainly engendered by the 1-y association. FM accretion from 0 to 4 mo was positively associated with linear growth from 1 to 5 y (β = 0.45; 95% CI: 0.02, 0.88; P = 0.038) in the fully adjusted model.Conclusions: In Ethiopian children, FFM accretion was associated with linear growth at 1 y and no clear additional longitudinal effect from 1 to 5 y was observed. FM accretion showed a weak association from 1 to 5 y. This trial was registered at www.controlled-trials.com as ISRCTN46718296.
KW - Faculty of Science
KW - Fat-free mass
KW - Fat mass
KW - Body composition
KW - Linear growth
KW - Height
KW - Length
KW - Children
U2 - 10.1093/jn/nxy003
DO - 10.1093/jn/nxy003
M3 - Journal article
C2 - 29659955
VL - 148
SP - 607
EP - 615
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 4
ER -
ID: 195554453