Added value of IP-10 as a read-out of Mycobacterium tuberculosis: Specific immunity in young children
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Added value of IP-10 as a read-out of Mycobacterium tuberculosis : Specific immunity in young children. / Jenum, Synne; Dhanasekaran, Sivmakumaran; Ritz, Christian; Macaden, Ragini; Doherty, T Mark; Grewal, Harleen M.S.; TB Trials Study Group.
In: Pediatric Infectious Disease Journal, Vol. 35, No. 12, 2016, p. 1336-1338.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Added value of IP-10 as a read-out of Mycobacterium tuberculosis
T2 - Specific immunity in young children
AU - Jenum, Synne
AU - Dhanasekaran, Sivmakumaran
AU - Ritz, Christian
AU - Macaden, Ragini
AU - Doherty, T Mark
AU - Grewal, Harleen M.S.
AU - TB Trials Study Group
N1 - CURIS 2016 NEXS 329
PY - 2016
Y1 - 2016
N2 - We have explored the added value of IFNγ-inducible protein 10 as a read-out of Mycobacterium tuberculosis specific immunity in young Indian children where the sensitivity of the IGRA for tuberculosis (TB) is poor. Reduced frequency of indeterminate results and an increased sensitivity for TB, suggest a potential for fewer missed cases with a combined IFNγ/IP-10 read-out in a 4 generation IGRA.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
AB - We have explored the added value of IFNγ-inducible protein 10 as a read-out of Mycobacterium tuberculosis specific immunity in young Indian children where the sensitivity of the IGRA for tuberculosis (TB) is poor. Reduced frequency of indeterminate results and an increased sensitivity for TB, suggest a potential for fewer missed cases with a combined IFNγ/IP-10 read-out in a 4 generation IGRA.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
KW - Faculty of Science
KW - Tuberculosis
KW - Child
KW - Tuberculin skin test
KW - Interferon-gamma release assay
KW - Cytokines
KW - Chemokines
U2 - 10.1097/INF.0000000000001328
DO - 10.1097/INF.0000000000001328
M3 - Journal article
C2 - 27642776
VL - 35
SP - 1336
EP - 1338
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 12
ER -
ID: 166239818