Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR
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Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR. / Ogasawara, Riki; Jensen, Thomas Elbenhardt; Goodman, Craig A; Hornberger, Troy A.
In: Exercise and Sport Sciences Reviews, Vol. 47, No. 3, 2019, p. 188-194.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR
AU - Ogasawara, Riki
AU - Jensen, Thomas Elbenhardt
AU - Goodman, Craig A
AU - Hornberger, Troy A
N1 - CURIS 2019 NEXS 249
PY - 2019
Y1 - 2019
N2 - The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.Summary: This review examines whether both rapamycin-sensitive, and rapamycin-insensitive, components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.
AB - The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.Summary: This review examines whether both rapamycin-sensitive, and rapamycin-insensitive, components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.
KW - Faculty of Science
KW - Exercise
KW - Hypertrophy
KW - Protein synthesis
KW - mTOR
KW - mTORC1
KW - mTORC2
KW - Rapamycin
U2 - 10.1249/JES.0000000000000189
DO - 10.1249/JES.0000000000000189
M3 - Review
C2 - 30870215
VL - 47
SP - 188
EP - 194
JO - Exercise and Sport Sciences Reviews
JF - Exercise and Sport Sciences Reviews
SN - 0091-6331
IS - 3
ER -
ID: 214870916