Rho GTPases-emerging regulators of glucose homeostasis and metabolic health
Research output: Contribution to journal › Review › Research › peer-review
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Rho GTPases-emerging regulators of glucose homeostasis and metabolic health. / Møller, Lisbeth Liliendal Valbjørn; Klip, Amira; Sylow, Lykke.
In: Cells, Vol. 8, No. 5, 434, 2019.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Rho GTPases-emerging regulators of glucose homeostasis and metabolic health
AU - Møller, Lisbeth Liliendal Valbjørn
AU - Klip, Amira
AU - Sylow, Lykke
N1 - CURIS 2019 NEXS 163
PY - 2019
Y1 - 2019
N2 - Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho GTPases are studied because of their function in cell migration and cancer, while their roles in metabolism are less documented. However, emerging evidence implicates Rho GTPases as regulators of processes of crucial importance for maintaining metabolic homeostasis. Thus, the time is now ripe for reviewing Rho GTPases in the context of metabolic health. Rho GTPase-mediated key processes include the release of insulin from pancreatic β cells, glucose uptake into skeletal muscle and adipose tissue, and muscle mass regulation. Through the current review, we cast light on the important roles of Rho GTPases in skeletal muscle, adipose tissue, and the pancreas and discuss the proposed mechanisms by which Rho GTPases act to regulate glucose metabolism in health and disease. We also describe challenges and goals for future research.
AB - Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho GTPases are studied because of their function in cell migration and cancer, while their roles in metabolism are less documented. However, emerging evidence implicates Rho GTPases as regulators of processes of crucial importance for maintaining metabolic homeostasis. Thus, the time is now ripe for reviewing Rho GTPases in the context of metabolic health. Rho GTPase-mediated key processes include the release of insulin from pancreatic β cells, glucose uptake into skeletal muscle and adipose tissue, and muscle mass regulation. Through the current review, we cast light on the important roles of Rho GTPases in skeletal muscle, adipose tissue, and the pancreas and discuss the proposed mechanisms by which Rho GTPases act to regulate glucose metabolism in health and disease. We also describe challenges and goals for future research.
KW - Faculty of Science
KW - Rho GTPases
KW - Metabolism
KW - Glucose homeostasis
KW - GLUT4 translocation
KW - Skeletal muscle
KW - Pancreas
KW - Insulin
KW - Diabetes
KW - Ageing
U2 - 10.3390/cells8050434
DO - 10.3390/cells8050434
M3 - Review
C2 - 31075957
VL - 8
JO - Cells
JF - Cells
SN - 2073-4409
IS - 5
M1 - 434
ER -
ID: 217938009