Stunting, wasting and breastfeeding as correlates of body composition in Cambodian children at 6 and 15 months of age
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Stunting, wasting and breastfeeding as correlates of body composition in Cambodian children at 6 and 15 months of age. / Skau, Jutta Kloppenborg Heick; Grenov, Benedikte; Chamnan, Chhoun; Mary, Chea; Wieringa, Frank T; Dijkhuizen, Marjoleine A; Ritz, Christian; Wells, Jonathan C; Berger, Jacques; Filteau, Suzanne; Roos, Nanna; Michaelsen, Kim F.; Friis, Henrik.
In: British Journal of Nutrition, Vol. 121, 2019, p. 688-698.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Stunting, wasting and breastfeeding as correlates of body composition in Cambodian children at 6 and 15 months of age
AU - Skau, Jutta Kloppenborg Heick
AU - Grenov, Benedikte
AU - Chamnan, Chhoun
AU - Mary, Chea
AU - Wieringa, Frank T
AU - Dijkhuizen, Marjoleine A
AU - Ritz, Christian
AU - Wells, Jonathan C
AU - Berger, Jacques
AU - Filteau, Suzanne
AU - Roos, Nanna
AU - Michaelsen, Kim F.
AU - Friis, Henrik
N1 - CURIS 2019 NEXS 063 (Embargo)
PY - 2019
Y1 - 2019
N2 - The study aimed at assessing stunting and wasting as correlates of body composition in Cambodian children. As part of a nutrition trial (ISRCTN19918531), fat (FM) and fat-free mass (FFM) were measured using 2H dilution at 6 and 15 months of age. Linear mixed-effects models were used to assess associations of stunting, wasting, sex and breastfeeding with FM and FFM and height-adjusted indexes FMI and FFMI. Of 419 infants enrolled, 98% were breastfed, 15% stunted and 4% wasted at 6 months. At 15 months, 78% were breastfed, 24% stunted and 11% wasted. Those not breastfed had lower FMI at 6 months (-1.22; 95% CI -2.05;-0.39) but not at 15 months (-0.23, -0.51;0.051). Stunted children had lower FM at 6 months and lower FFM at 6 and 15 months compared to children with length-for-age ≥0 Z. Stunting was not associated with FMI or FFMI. Wasted children had lower FM, FFM, FMI and FFMI at 6 and 15 months compared to children with weight-for-length z (WLZ) ≥0. Generally, FFM and FFMI deficits increased with age, whereas FM and FMI deficits decreased, reflecting interactions between age and WLZ. For example, the FFM deficits were -0.99 (-1.26;-0.72) kg at 6 months, and -1.44 (-1.69; -1.19) kg at 15 months (interaction, p<0.05), while the FMI deficits were -2.12 (-2.53;-1.72) kg/m2 at 6 months and -1.32 (-1.77;-0.87) kg/m2 at 15 months (interaction, P<0.05). This indicates that undernourished children preserve body fat at the detriment of fat-free tissue, which may have long-term consequences for health and working capacity.
AB - The study aimed at assessing stunting and wasting as correlates of body composition in Cambodian children. As part of a nutrition trial (ISRCTN19918531), fat (FM) and fat-free mass (FFM) were measured using 2H dilution at 6 and 15 months of age. Linear mixed-effects models were used to assess associations of stunting, wasting, sex and breastfeeding with FM and FFM and height-adjusted indexes FMI and FFMI. Of 419 infants enrolled, 98% were breastfed, 15% stunted and 4% wasted at 6 months. At 15 months, 78% were breastfed, 24% stunted and 11% wasted. Those not breastfed had lower FMI at 6 months (-1.22; 95% CI -2.05;-0.39) but not at 15 months (-0.23, -0.51;0.051). Stunted children had lower FM at 6 months and lower FFM at 6 and 15 months compared to children with length-for-age ≥0 Z. Stunting was not associated with FMI or FFMI. Wasted children had lower FM, FFM, FMI and FFMI at 6 and 15 months compared to children with weight-for-length z (WLZ) ≥0. Generally, FFM and FFMI deficits increased with age, whereas FM and FMI deficits decreased, reflecting interactions between age and WLZ. For example, the FFM deficits were -0.99 (-1.26;-0.72) kg at 6 months, and -1.44 (-1.69; -1.19) kg at 15 months (interaction, p<0.05), while the FMI deficits were -2.12 (-2.53;-1.72) kg/m2 at 6 months and -1.32 (-1.77;-0.87) kg/m2 at 15 months (interaction, P<0.05). This indicates that undernourished children preserve body fat at the detriment of fat-free tissue, which may have long-term consequences for health and working capacity.
KW - Faculty of Science
KW - Body composition
KW - Fat-free mass
KW - Fat mass
KW - Infancy
KW - Childhood
KW - Breastfeeding
KW - Stunting
KW - Wasting
U2 - 10.1017/S0007114518003884
DO - 10.1017/S0007114518003884
M3 - Journal article
C2 - 30670108
VL - 121
SP - 688
EP - 698
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
ER -
ID: 212904408