Suboptimal nutrition and low physical activity are observed together with reduced plasma brain-derived neurotrophic factor (BDNF) concentration in children with severe cerebral palsy (CP)
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Suboptimal nutrition and low physical activity are observed together with reduced plasma brain-derived neurotrophic factor (BDNF) concentration in children with severe cerebral palsy (CP). / Hansen, Solvejg Lis; Lorentzen, Jakob; Pedersen, Lin T; Hendrich, Frederikke L; Jorsal, Martin; Pingel, Jessica; Nielsen, Jens Bo; Kiens, Bente.
In: Nutrients, Vol. 11, No. 3, 620, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Suboptimal nutrition and low physical activity are observed together with reduced plasma brain-derived neurotrophic factor (BDNF) concentration in children with severe cerebral palsy (CP)
AU - Hansen, Solvejg Lis
AU - Lorentzen, Jakob
AU - Pedersen, Lin T
AU - Hendrich, Frederikke L
AU - Jorsal, Martin
AU - Pingel, Jessica
AU - Nielsen, Jens Bo
AU - Kiens, Bente
N1 - CURIS 2019 NEXS 096
PY - 2019
Y1 - 2019
N2 - Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I⁻II, n = 31, age 10.6 ± 0.6 years), severe CP (GMFCS IV⁻V, n = 14, age 10.9 ± 1.1 years) and typically developed (TD) children (n = 22, age 10.9 ± 0.6 years). Children with severe CP had ~40% lower plasma BDNF concentration than TD children (p < 0.05). Furthermore, children with severe CP had lower daily physical activity level than TD children (p < 0.01), and a daily intake of energy, n-3 fatty acids, and dietary fibers that was only ~50% of TD (p > 0.001). Reduced plasma BDNF concentrations were observed in children with severe CP. This may be of significance for optimal neural growth and plasticity. This was observed together with low physical activity levels and a suboptimal intake of energy, n-3 fatty acids, and dietary fibers.
AB - Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I⁻II, n = 31, age 10.6 ± 0.6 years), severe CP (GMFCS IV⁻V, n = 14, age 10.9 ± 1.1 years) and typically developed (TD) children (n = 22, age 10.9 ± 0.6 years). Children with severe CP had ~40% lower plasma BDNF concentration than TD children (p < 0.05). Furthermore, children with severe CP had lower daily physical activity level than TD children (p < 0.01), and a daily intake of energy, n-3 fatty acids, and dietary fibers that was only ~50% of TD (p > 0.001). Reduced plasma BDNF concentrations were observed in children with severe CP. This may be of significance for optimal neural growth and plasticity. This was observed together with low physical activity levels and a suboptimal intake of energy, n-3 fatty acids, and dietary fibers.
KW - Faculty of Science
KW - Dietary registration
KW - Maximal oxygen uptake
KW - Blood sampling
KW - Energy
KW - Dietary fibers
KW - n-3 fatty acids
KW - DHA
KW - Plasticity
KW - Cerebral palsy
U2 - 10.3390/nu11030620
DO - 10.3390/nu11030620
M3 - Journal article
C2 - 30875771
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 620
ER -
ID: 215031944