A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial
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A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial. / Magkos, Faidon; Hjorth, Mads Fiil; Asping, Sarah; Rosenkrans, Maria I; Rasmussen, Sidse Ingemann; Ritz, Christian; Sjödin, Anders; Geiker, Nina Rica Wium.
In: Clinical Nutrition, Vol. 40, No. 12, 2021, p. 5726-5733.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial
AU - Magkos, Faidon
AU - Hjorth, Mads Fiil
AU - Asping, Sarah
AU - Rosenkrans, Maria I
AU - Rasmussen, Sidse Ingemann
AU - Ritz, Christian
AU - Sjödin, Anders
AU - Geiker, Nina Rica Wium
N1 - Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background & aims: The European Food Safety Authority recently recommended an increase in the protein content of total diet replacement (TDR) products from 50 to 75 g/day. The rationale was to minimize reductions in lean mass (LM) and resting metabolic rate (RMR) that occur with weight loss, and thereby facilitate maintenance of lost weight. We sought to directly compare the efficacy of TDR regimens with the new vs the current protein requirement.Methods: We randomized 108 adults with overweight or obesity (body mass index 28-40 kg/m2) to very-low-calorie diets (VLCD) with either 52 or 77 g/day protein for 8 weeks (total energy intake of 600 or 700 kcal/day, respectively). LM was determined by dual energy X-ray absorptiometry and RMR by indirect calorimetry.Results: Attrition rate was 22% in both groups. Both VLCDs decreased body weight, fat mass, LM, and RMR (all P < 0.05). Significant time-by-group interactions were detected for weight and fat mass (both P < 0.05), with corresponding reductions being smaller in the higher-protein than the standard-protein VLCD, likely because of the added calories. On the other hand, reductions in LM (6% from baseline) and RMR (9-10% from baseline) did not differ between groups (P = 0.155 and P = 0.389, respectively), and the contribution of LM to total weight loss was identical (27 ± 2% of lost weight, P = 0.973).Conclusions: Our results indicate that the proposed increase in the protein content of TDR products does not attenuate reductions in LM and RMR in individuals with overweight and obesity who are treated with <800 kcal/day VLCDs for 2 months.Clinical trial registry: ClinicalTrials.gov # NCT04156165.
AB - Background & aims: The European Food Safety Authority recently recommended an increase in the protein content of total diet replacement (TDR) products from 50 to 75 g/day. The rationale was to minimize reductions in lean mass (LM) and resting metabolic rate (RMR) that occur with weight loss, and thereby facilitate maintenance of lost weight. We sought to directly compare the efficacy of TDR regimens with the new vs the current protein requirement.Methods: We randomized 108 adults with overweight or obesity (body mass index 28-40 kg/m2) to very-low-calorie diets (VLCD) with either 52 or 77 g/day protein for 8 weeks (total energy intake of 600 or 700 kcal/day, respectively). LM was determined by dual energy X-ray absorptiometry and RMR by indirect calorimetry.Results: Attrition rate was 22% in both groups. Both VLCDs decreased body weight, fat mass, LM, and RMR (all P < 0.05). Significant time-by-group interactions were detected for weight and fat mass (both P < 0.05), with corresponding reductions being smaller in the higher-protein than the standard-protein VLCD, likely because of the added calories. On the other hand, reductions in LM (6% from baseline) and RMR (9-10% from baseline) did not differ between groups (P = 0.155 and P = 0.389, respectively), and the contribution of LM to total weight loss was identical (27 ± 2% of lost weight, P = 0.973).Conclusions: Our results indicate that the proposed increase in the protein content of TDR products does not attenuate reductions in LM and RMR in individuals with overweight and obesity who are treated with <800 kcal/day VLCDs for 2 months.Clinical trial registry: ClinicalTrials.gov # NCT04156165.
KW - Faculty of Science
KW - Weight loss
KW - Protein
KW - Fat-free mass
KW - Low-calorie diet
KW - Resting energy expenditure
U2 - 10.1016/j.clnu.2021.10.006
DO - 10.1016/j.clnu.2021.10.006
M3 - Journal article
C2 - 34749132
VL - 40
SP - 5726
EP - 5733
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 12
ER -
ID: 284397700