Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis
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Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis. / van Rossem, Lenie; Smit, Henriette A; Armand, Martine; Bernard, Jonathan Y; Bisgaard, Hans; Bønnelykke, Klaus; Bruun, Signe; Heude, Barbara; Husby, Steffen; Kyhl, Henriette Boye; Michaelsen, Kim F.; Stark, Ken D; Thijs, Carel; Vinding, Rebecca Kofod; Wijga, Alet H; Lauritzen, Lotte.
In: European Journal of Nutrition, Vol. 60, No. 2, 2021, p. 989-998.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis
AU - van Rossem, Lenie
AU - Smit, Henriette A
AU - Armand, Martine
AU - Bernard, Jonathan Y
AU - Bisgaard, Hans
AU - Bønnelykke, Klaus
AU - Bruun, Signe
AU - Heude, Barbara
AU - Husby, Steffen
AU - Kyhl, Henriette Boye
AU - Michaelsen, Kim F.
AU - Stark, Ken D
AU - Thijs, Carel
AU - Vinding, Rebecca Kofod
AU - Wijga, Alet H
AU - Lauritzen, Lotte
N1 - CURIS 2021 NEXS 077
PY - 2021
Y1 - 2021
N2 - Purpose: It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.Methods: We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations.Results: A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages.Conclusion: In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.
AB - Purpose: It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.Methods: We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations.Results: A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages.Conclusion: In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.
KW - Faculty of Science
KW - Breastfeeding
KW - Blood pressure
KW - Fatty acids
KW - Children
U2 - 10.1007/s00394-020-02310-4
DO - 10.1007/s00394-020-02310-4
M3 - Journal article
C2 - 32564149
VL - 60
SP - 989
EP - 998
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 2
ER -
ID: 243342452