Diets, nutrients, genes and the microbiome: Recent advances in personalised nutrition
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Diets, nutrients, genes and the microbiome: Recent advances in personalised nutrition. / Matusheski, Nathan; Caffrey, Aoife; Christensen, Lars; Mezgec, Simon; Surendran, Shelini; Hjorth, Mads Fiil; McNulty, Helene; Pentieva, Kristina; Roager, Henrik Munch; Seljak, Barbara Koroušić; Vimaleswaran, Karani Santhanakrishnan; Remmers, Marcus; Peter, Szabolcs.
In: British Journal of Nutrition, Vol. 126, No. 10, 2021, p. 1489-1497.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Diets, nutrients, genes and the microbiome: Recent advances in personalised nutrition
AU - Matusheski, Nathan
AU - Caffrey, Aoife
AU - Christensen, Lars
AU - Mezgec, Simon
AU - Surendran, Shelini
AU - Hjorth, Mads Fiil
AU - McNulty, Helene
AU - Pentieva, Kristina
AU - Roager, Henrik Munch
AU - Seljak, Barbara Koroušić
AU - Vimaleswaran, Karani Santhanakrishnan
AU - Remmers, Marcus
AU - Peter, Szabolcs
N1 - CURIS 2021 NEXS 100
PY - 2021
Y1 - 2021
N2 - As individuals seek increasingly individualised nutrition and lifestyle guidance, numerous apps and nutrition programs have emerged. However, complex individual variations in dietary behaviours, genotypes, gene expression and composition of the microbiome are increasingly recognised. Advances in digital tools and artificial intelligence can help individuals more easily track nutrient intakes and identify nutritional gaps. However, the influence of these nutrients on health outcomes can vary widely among individuals depending upon life stage, genetics and microbial composition. For example, folate may elicit favourable epigenetic effects on brain development during a critical developmental time window of pregnancy. Genes affecting vitamin B12 metabolism may lead to cardiometabolic traits that play an essential role in the context of obesity. Finally, an individual's gut microbial composition can determine their response to dietary fibre interventions during weight loss. These recent advances in understanding can lead to a more complete and integrated approach to promoting optimal health through personalised nutrition, in clinical practise settings and for individuals in their daily lives. The purpose of this review is to summarise presentations made during the DSM Science and Technology Award Symposium at the 13th European Nutrition Conference, which focused on personalised nutrition and novel technologies for health in the modern world.
AB - As individuals seek increasingly individualised nutrition and lifestyle guidance, numerous apps and nutrition programs have emerged. However, complex individual variations in dietary behaviours, genotypes, gene expression and composition of the microbiome are increasingly recognised. Advances in digital tools and artificial intelligence can help individuals more easily track nutrient intakes and identify nutritional gaps. However, the influence of these nutrients on health outcomes can vary widely among individuals depending upon life stage, genetics and microbial composition. For example, folate may elicit favourable epigenetic effects on brain development during a critical developmental time window of pregnancy. Genes affecting vitamin B12 metabolism may lead to cardiometabolic traits that play an essential role in the context of obesity. Finally, an individual's gut microbial composition can determine their response to dietary fibre interventions during weight loss. These recent advances in understanding can lead to a more complete and integrated approach to promoting optimal health through personalised nutrition, in clinical practise settings and for individuals in their daily lives. The purpose of this review is to summarise presentations made during the DSM Science and Technology Award Symposium at the 13th European Nutrition Conference, which focused on personalised nutrition and novel technologies for health in the modern world.
KW - Faculty of Science
KW - Personalised nutrition
KW - Automated food image recognition
KW - Deep learning
KW - Cognition
KW - Epigenetics
KW - Folate
KW - Pregnancy
KW - Genetics
KW - Vitamin B12
KW - Cardiometabolic disease
KW - Obesity
KW - Enterotype
KW - Prevotella
KW - Bacteroides
U2 - 10.1017/S0007114521000374
DO - 10.1017/S0007114521000374
M3 - Review
C2 - 33509307
VL - 126
SP - 1489
EP - 1497
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
ER -
ID: 256160926