Exercise - a panacea of metabolic dysregulation in cancer: Physiological and molecular insights
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Exercise - a panacea of metabolic dysregulation in cancer: Physiological and molecular insights. / Raun, Steffen Henning; Buch-Larsen, Kristian; Schwarz, Peter; Sylow, Lykke.
In: International Journal of Molecular Sciences, Vol. 22, No. 7, 3469, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Exercise - a panacea of metabolic dysregulation in cancer: Physiological and molecular insights
AU - Raun, Steffen Henning
AU - Buch-Larsen, Kristian
AU - Schwarz, Peter
AU - Sylow, Lykke
N1 - CURIS 2021 NEXS 124
PY - 2021
Y1 - 2021
N2 - Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced survival. Current evidence suggests many health benefits from exercise during and after cancer treatment, yet only a limited number of studies have addressed the effect of exercise on cancer-associated disruption of metabolism. In this review, we draw on studies in cells, rodents, and humans to describe the metabolic dysfunctions observed in cancer and the tissues involved. We discuss how the known effects of acute exercise and exercise training observed in healthy subjects could have a positive outcome on mechanisms in people with cancer, namely: insulin resistance, hyperlipidemia, mitochondrial dysfunction, inflammation, and cachexia. Finally, we compile the current limited knowledge of how exercise corrects metabolic control in cancer and identify unanswered questions for future research.
AB - Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced survival. Current evidence suggests many health benefits from exercise during and after cancer treatment, yet only a limited number of studies have addressed the effect of exercise on cancer-associated disruption of metabolism. In this review, we draw on studies in cells, rodents, and humans to describe the metabolic dysfunctions observed in cancer and the tissues involved. We discuss how the known effects of acute exercise and exercise training observed in healthy subjects could have a positive outcome on mechanisms in people with cancer, namely: insulin resistance, hyperlipidemia, mitochondrial dysfunction, inflammation, and cachexia. Finally, we compile the current limited knowledge of how exercise corrects metabolic control in cancer and identify unanswered questions for future research.
KW - Faculty of Science
KW - Cancer
KW - Metabolism
KW - Exercise
KW - Skeletal muscle
KW - Insulin resistance
KW - Adipose tissue
KW - Cancer cachexia
U2 - 10.3390/ijms22073469
DO - 10.3390/ijms22073469
M3 - Review
C2 - 33801684
VL - 22
JO - International Journal of Molecular Sciences (CD-ROM)
JF - International Journal of Molecular Sciences (CD-ROM)
SN - 1424-6783
IS - 7
M1 - 3469
ER -
ID: 259571496