Exercise - a panacea of metabolic dysregulation in cancer: Physiological and molecular insights
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Documents
- Raun et al_International Journal of Molecular Sciences_2021_Vol 22(7)_e3469
Final published version, 1.5 MB, PDF document
Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced survival. Current evidence suggests many health benefits from exercise during and after cancer treatment, yet only a limited number of studies have addressed the effect of exercise on cancer-associated disruption of metabolism. In this review, we draw on studies in cells, rodents, and humans to describe the metabolic dysfunctions observed in cancer and the tissues involved. We discuss how the known effects of acute exercise and exercise training observed in healthy subjects could have a positive outcome on mechanisms in people with cancer, namely: insulin resistance, hyperlipidemia, mitochondrial dysfunction, inflammation, and cachexia. Finally, we compile the current limited knowledge of how exercise corrects metabolic control in cancer and identify unanswered questions for future research.
Original language | English |
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Article number | 3469 |
Journal | International Journal of Molecular Sciences |
Volume | 22 |
Issue number | 7 |
Number of pages | 23 |
ISSN | 1424-6783 |
DOIs | |
Publication status | Published - 2021 |
- Faculty of Science - Cancer, Metabolism, Exercise, Skeletal muscle, Insulin resistance, Adipose tissue, Cancer cachexia
Research areas
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