Factors mediating exercise-induced organ crosstalk
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Factors mediating exercise-induced organ crosstalk. / Sabaratnam, Rugivan; Wojtaszewski, Jørgen; Højlund, Kurt.
In: Acta Physiologica, Vol. 234, No. 2, e13766, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Factors mediating exercise-induced organ crosstalk
AU - Sabaratnam, Rugivan
AU - Wojtaszewski, Jørgen
AU - Højlund, Kurt
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise may ameliorate and prevent the development of several chronic metabolic diseases. Skeletal muscle is recognized as an important endocrine organ regulating systemic adaptations to exercise. Skeletal muscle may mediate crosstalk with other organs through the release of exercise-induced cytokines, peptides and proteins, termed myokines, into the circulation. Importantly, other tissues such as the liver and adipose tissue may also release cytokines and peptides in response to exercise. Hence, exercise-released molecules are collectively called exerkines. Moreover, extracellular vesicles (EVs), in the form of exosomes or microvesicles, may carry some of the signals involved in tissue crosstalk. This review focuses on the role of factors potentially mediating crosstalk between muscle and other tissues in response to exercise.
AB - Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise may ameliorate and prevent the development of several chronic metabolic diseases. Skeletal muscle is recognized as an important endocrine organ regulating systemic adaptations to exercise. Skeletal muscle may mediate crosstalk with other organs through the release of exercise-induced cytokines, peptides and proteins, termed myokines, into the circulation. Importantly, other tissues such as the liver and adipose tissue may also release cytokines and peptides in response to exercise. Hence, exercise-released molecules are collectively called exerkines. Moreover, extracellular vesicles (EVs), in the form of exosomes or microvesicles, may carry some of the signals involved in tissue crosstalk. This review focuses on the role of factors potentially mediating crosstalk between muscle and other tissues in response to exercise.
KW - Faculty of Science
KW - Exercise
KW - Skeletal muscle
KW - Myokines
KW - Exerkines
KW - Hepatokines
KW - Crosstalk
KW - Exosomes
U2 - 10.1111/apha.13766
DO - 10.1111/apha.13766
M3 - Review
C2 - 34981891
VL - 234
JO - Acta Physiologica
JF - Acta Physiologica
SN - 1748-1708
IS - 2
M1 - e13766
ER -
ID: 288854853