Factors mediating exercise-induced organ crosstalk
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Documents
- Sabaratnam et al_Acta Physiologica_2022_e13766_(Accepted manuscript)
Accepted author manuscript, 18.2 MB, PDF document
Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise may ameliorate and prevent the development of several chronic metabolic diseases. Skeletal muscle is recognized as an important endocrine organ regulating systemic adaptations to exercise. Skeletal muscle may mediate crosstalk with other organs through the release of exercise-induced cytokines, peptides and proteins, termed myokines, into the circulation. Importantly, other tissues such as the liver and adipose tissue may also release cytokines and peptides in response to exercise. Hence, exercise-released molecules are collectively called exerkines. Moreover, extracellular vesicles (EVs), in the form of exosomes or microvesicles, may carry some of the signals involved in tissue crosstalk. This review focuses on the role of factors potentially mediating crosstalk between muscle and other tissues in response to exercise.
Original language | English |
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Article number | e13766 |
Journal | Acta Physiologica |
Volume | 234 |
Issue number | 2 |
Number of pages | 20 |
ISSN | 1748-1708 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
This article is protected by copyright. All rights reserved.
- Faculty of Science - Exercise, Skeletal muscle, Myokines, Exerkines, Hepatokines, Crosstalk, Exosomes
Research areas
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